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Aflatoxin B1, crystalline, Thermo Scientific Chemicals
Aflatoxin B1, crystalline, CAS # 1162-65-8, is a member of a group of mycotoxins presenting potent hepatotoxic and carcinogenic activities.
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Chemical Identifiers
CAS1162-65-8
IUPAC Name11-methoxy-6,8,19-trioxapentacyclo[10.7.0.0²,⁹.0³,⁷.0¹³,¹⁷]nonadeca-1,4,9,11,13(17)-pentaene-16,18-dione
Molecular FormulaC17H12O6
InChI KeyOQIQSTLJSLGHID-UHFFFAOYNA-N
SMILESCOC1=C2C3=C(C(=O)CC3)C(=O)OC2=C2C3C=COC3OC2=C1
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Specification SheetThis Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Information
• Aflatoxin B1 (AFB1) is a member of a group of mycotoxins produced by Aspergillus flavus, and Aspergillus parasiticus showing carcinogenic activities
• AFB1 can induce the transversion of G to T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in a mutation and promoting the carcinogenic process
Applications
• Aflatoxin B1 shows teratogenic activity
• It is a CYP1A2, CYP2A6, CYP2D6, and CYP3A substrate and can be used to study the CYP family in in vitro and in vivo studies.
• It can cause immunosuppression in animal models.
RUO – Research Use Only
General References:
- Aguilar, F.; Hussain, S.; Cerutti, P. Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci U S A. 1993, 90, (18), 8586-8590.
- Diaz, G.; Murcia, H.; Cepeda, S. Cytochrome P450 enzymes involved in the metabolism of aflatoxin B1 in chickens and quail. Poult Sci. 2010, 89, (11), 2461-2469.
- Meissonnier, G.; Pinton, P.; Laffitte, J. Immunotoxicity of aflatoxin B1: Impairment of the cell-mediated response to vaccine antigen and modulation of cytokine expression. Toxicology and Applied Pharmacology. 2008, 231, 142–149.
- McLean, M.; Dutton, M. Cellular interactions and metabolism of aflatoxin: an update. Pharmacology & Therapeutics. 1995, 65, 2, 163-192.
- Galvano, F.; Ritieni, A.; Piva, G.; Pietri, A. Mycotoxins in the human food chain. In: Diaz D.E., editor. The Mycotoxin Blue Book. Nottingham University Press; Nottingham, UK: 2005. pp. 187–224.