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Prednisone, 98%, Thermo Scientific Chemicals
Prednisone, 98%, Thermo Scientific Chemicals
Prednisone, 98%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Prednisone, 98%, Thermo Scientific Chemicals

Prednisone, 98%, CAS # 53-03-2, is a synthetic glucocorticoid with anti-inflammatory, immunomodulatory, antineoplastic, and adrenergic activities.
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Catalog NumberQuantityPackaging
44895025025gGlass Bottle
4489500505gGlass bottle
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Catalog number 448950250
Price (TWD)
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Quantity:
25g
Packaging:
Glass Bottle
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Chemical Identifiers
CAS53-03-2
IUPAC Name(1R,3aS,3bS,9aR,9bS,11aS)-1-hydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-7,10-dione
Molecular FormulaC21H26O5
InChI KeyXOFYZVNMUHMLCC-ZPOLXVRWSA-N
SMILESC[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
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SpecificationsSpecification SheetSpecification Sheet
Specific optical rotation+165° to +175° (20°C, 589 nm) (c=0.5, dioxane)
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities

• It shows antineoplastic and adrenergic activities against hormone-sensitive cancer cells

• This compound binds to its receptors and enters the nucleus activating specific nuclear receptors, resulting in an altered gene expression and inhibiting proinflammatory cytokine production

Applications

• Prednisone can reduce circulating lymphocytes, promote cell differentiation, and stimulate apoptosis in sensitive tumor cell lines

• It is considered a prodrug that is converted by the liver into prednisolone which is the active steroid compound

• It is also used in some studies to investigate the effects of daily administration of MIDD0301, on the animal and organs weights and hematological profile

RUO – Research Use Only

Literature References

Zahn, N.M.; Huber, A.T.; Mikulsky, B.N.; Stepanski, M.E.; Kehoe, A.S.; Li, G.; Schussman, M.; Rashid Roni, M.S.; Kodali, R.; Cook, J.M.; Stafford, D.C.; Steeber, D.A.; Arnold, L.A. MIDD0301 - A first-in-class anti-inflammatory asthma drug targets GABAA receptors without causing systemic immune suppression. Basic Clin Pharmacol Toxicol. 2019, 125(1), 75-84.