Daptomycin

Daptomycin, CAS # 103060-53-3, is a semi-synthetic polypeptide antibiotic that has bactericidal activity against vancomycin-resistant gram-positive bacteria.

Catalog Number	Quantity
461371000	100mg

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Catalog number 461371000

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100mg

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Chemical Identifiers

CAS103060-53-3

IUPAC Name(3S)-3-{[(3S,6S,9R,15S,18R,21S,24S)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-(1-carboxypropan-2-yl)-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]carbamoyl}-3-[(2S)-3-carbamoyl-2-[(2S)-2-decanamido-3-(1H-indol-3-yl)propanamido]propanamido]propanoic acid

Molecular FormulaC72H101N17O26

InChI KeyDOAKLVKFURWEDJ-OFNKPWESSA-N

SMILESCCCCCCCCCC(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NC1C(C)OC(=O)[C@H](CC(=O)C2=CC=CC=C2N)NC(=O)[C@@H](NC(=O)[C@@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN)NC(=O)CNC1=O)C(C)CC(O)=O

Specifications

HPLC>=93 %

Loss on drying=<10 %

Appearance (Color)White to brown

Appearance (Form)Powder

Infrared spectrumConforms

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Daptomycin is an antibiotic that activity against vancomycin-resistant gram-positive bacteria including enterococci and Staphylococcus aureus

Applications

• It has bactericidal activity against vancomycin-resistant gram-positive bacteria

• It can bind the bacterial cell membrane causing disruption of the membrane and increasing efflux of potassium ions from bacterial cells, disrupting protein, DNA, and RNA synthesis

RUO – Research Use Only

Literature References

Kosmidis, C. and Levine, D.P., 2010. Expert Opin. Pharmacother. 11, 615. Cui, L., et al. 2006. Antimicrob. Agents Chemother. 50, 1079. Silverman, J.A., et al. 2003. Antimicrob. Agents Chemother. 47, 2538. Rybak, M.J., et al. 2000. Antimicrob. Agents Chemother. 44, 1062.