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Thermo Scientific Chemicals
Triethyl 4-phosphonocrotonate, cis + trans, 94%
CAS: 10236-14-3 | C10H19O5P | 250.23 g/mol
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Catalog number A10995.14
also known as A10995-14
Price (TWD)
-
Quantity:
25 g
Chemical Identifiers
CAS10236-14-3
Specifications
Specification Sheet
Specification SheetRefractive Index1.4510-1.4580 @ 20?C
Appearance (Color)Clear colorless to yellow
FormLiquid
Assay (GC)≥92.0%
Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
RUO – Research Use Only
General References:
- Xiao-Ping Song; Camille Bouillon; Eveline Lescrinier; Piet Herdewijn. Iminodipropionic acid as the leaving group for DNA polymerization by HIV-1 reverse transcriptase. ChemBioChem. 2011, 12,(12), 1868-1880.
- George Kokotos; Yuan-Hao Hsu; John E.Burke; Constantinos Baskakis; Christoforos G.Kokotos; Victoria Magrioti; Edward A.Dennis. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. Journal of medicinal and pharmaceutical chemistry. 2010, 53,(9), 3602-3610.
- Wadsworth-Emmons reaction with carbonyl compounds leads to conjugated dienoic esters. Use of LiHMDS or LDA as base results in a high proportion of the (E,E)-isomer: J. Am. Chem. Soc., 100, 3599 (1978).