Thermo Scientific™

BioPharma Finder™ Software for the Characterization of Biotherapeutics

Simplify comprehensive biotherapeutic attribute characterization with advanced capabilities to increase throughput and confidence in a connected environment.

Catalog Number	Includes
BIOPHARMAFINDER5	BioPharma Finder 5.5

Catalog number BIOPHARMAFINDER5

Price (TWD)

Includes:

BioPharma Finder 5.5

Thermo Scientific™ BioPharma Finder™ software offers purpose-built data processing, curation, and reporting in a connected environment, enabling streamlined collaboration on a local and global scale. Simplify the characterization of biotherapeutic attributes with advanced capabilities that increase efficiency and confidence in BioPharma workflows. Leverage the high quality HRAM data generated by Thermo Scientific™ Orbitrap™ mass spectrometers, to efficiently screen, identify, and characterize proteins and oligonucleotides with greater productivity and confidence. Experience the power of BioPharma Finder software connected to the Thermo Scientific™ Ardia™ Platform to unlock enhanced features including data security, remote accessibility, collaboration tools, and interactive reporting, all tailored to streamline your BioPharma workflows.

Workflow-driven characterization, method processing, and result review

Peptide mapping workflow:

Validate amino acid assignments with a novel MS2 prediction algorithm, providing an added layer of certainty to confirm the accuracy of the amino acid sequence
Characterize site-specific expected and unknown post-translational modifications (PTMs), and utilize error-tolerant searches to identify unexpected modifications
Map disulfide bonds, create de novo sequence searches, and accurately detect low-level impurities and sequence variants for comprehensive analysis
Experience streamlined processes, including the Multi-Attribute Method (MAM) workflow to span from discovery peptide mapping to critical quality attributes (CQAs) monitoring in GMP environments

Oligonucleotide workflow:

Automated annotation and confirmation of oligonucleotide sequence with a novel MS2 prediction algorithm
Construct oligonucleotide sequences with built in customized building block subunits, including base, backbone linker, 2' ribose, 3' terminal and 5' terminal

Intact protein workflow:

Rapidly measure the intact molecular weight of biotherapeutics, including proteins and oligonucleotides, with built in deconvolution algorithms
Protein sequence matching to annotate N-linked glycosylations and common modifications
Confident identification of Antibody Drug Conjugates (ADC) and Drug Antibody Ratio (DAR) determination using sliding window algorithm

Top down workflow:

Features a simple workflow for sequencing intact protein molecules using ProSightBP as the core algorithm
Includes multiple raw file comparison with combined interactive fragmentation coverage maps
Supports multiple modes of fragmentation CID, HCD, ETD, EThcD and UVPD

Ardia Platform:

Features: Reporting, data security, collaboration

Specifications

For Use With (Application)BioPharma

For Use With (Equipment)Mass Spectrometers

IncludesBioPharma Finder 5.5

Software5.5

TechniqueMS

TypeSoftware

Unit SizeEach

Frequently asked questions (FAQs)

How does Thermo Scientific BioPharma Finder software support transition from characterization to QC or monitoring workflows?

Thermo Scientific BioPharma Finder software supports the transition from characterization to monitoring workflows by allowing users to export identified attributes and findings for use in downstream analysis. For example, process or product quality attributes identified during characterization can be transferred into monitoring workflows in other software environments. The software also includes templates for multi-attribute monitoring workflows, helping laboratories move from early-stage development toward quality control applications.

How does Thermo Scientific BioPharma Finder software help improve productivity and data interpretation?

Thermo Scientific BioPharma Finder software includes automated data processing workflows that can help reduce manual intervention and support more efficient analysis of complex datasets. It uses high-resolution mass spectrometry data and advanced algorithms to support sequence confirmation and characterization. The software also includes visualization tools such as sequence coverage maps and modification tables, which help users interpret results and understand biologic structure and variability.

What types of biologic samples can Thermo Scientific BioPharma Finder software support?

Thermo Scientific BioPharma Finder software supports a variety of biologic sample types, including monoclonal antibodies, antibody-drug conjugates (ADCs), oligonucleotides, mRNA therapeutics, and host cell proteins. It can be used for applications such as sequence mapping, impurity analysis, and degradation profiling.

When should I use Thermo Scientific BioPharma Finder software for biotherapeutic analysis?

Thermo Scientific BioPharma Finder software is suitable for laboratories performing characterization of biotherapeutics such as proteins, monoclonal antibodies, and oligonucleotides using high-resolution accurate-mass mass spectrometry data. It is commonly used for workflows such as peptide mapping, intact mass analysis, top-down and middle-down protein analysis, multi-attribute method development, and host cell protein profiling. It may be especially useful for laboratories that need to analyze complex biologics and generate detailed characterization data across multiple workflows.