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Thermo Scientific Chemicals
7-Bromoisatin, 97%
CAS: 20780-74-9 | C8H4BrNO2 | 226.029 g/mol
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Chemical Identifiers
CAS20780-74-9
IUPAC Name7-bromo-2,3-dihydro-1H-indole-2,3-dione
Molecular FormulaC8H4BrNO2
InChI KeyOCVKSIWBTJCXPV-UHFFFAOYSA-N
SMILESBrC1=CC=CC2=C1NC(=O)C2=O
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Specifications
Specification Sheet
Specification SheetAppearance (Color)Red
FormCrystals or powder or crystalline powder
Assay (HPLC)≥96.0%
Melting Point (clear melt)194.0-203.0?C
7-bromoisatin was treated with excess PhMgBr to afford tertiary alcohol 9 in 96 % yield. Isatin oxime triflates undergo a facile fragmentation which is promoted by DBU, to form anthranilonitriles after hydrolytic work-up.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
7-bromoisatin was treated with excess PhMgBr to afford tertiary alcohol 9 in 96 % yield. Isatin oxime triflates undergo a facile fragmentation which is promoted by DBU, to form anthranilonitriles after hydrolytic work-up.
Solubility
Slightly soluble.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
7-bromoisatin was treated with excess PhMgBr to afford tertiary alcohol 9 in 96 % yield. Isatin oxime triflates undergo a facile fragmentation which is promoted by DBU, to form anthranilonitriles after hydrolytic work-up.
Solubility
Slightly soluble.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
RUO – Research Use Only
General References:
- K. C. Nicolaou,; Marco Bella,; David Y.-K. Chen,; Xianhai Huang,; Taotao Ling,; Scott A. Snyder.Total Synthesis of Diazonamide A. Angew. Chem. Int. Ed. 2002, 41(18), pg no.
- James B. Campbell Jr.,; Timothy V. Davenport. Synthesis of Anthranilonitriles by Fragmentation of Isatin Oxime Triflates. Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry. 1989, 19 (13-14), 2255-2263.