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Thermo Scientific Chemicals
3,3',5-Triiodo-L-thyronine, 95%
CAS: 6893-02-3 | C15H12I3NO4 | 650.98 g/mol
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Chemical Identifiers
CAS6893-02-3
IUPAC Name2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
Molecular FormulaC15H12I3NO4
InChI KeyAUYYCJSJGJYCDS-UHFFFAOYNA-N
SMILESNC(CC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1)C(O)=O
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Specifications
Specification Sheet
Specification SheetAppearance (Color)White to cream to yellow to pale brown
FormPowder
Assay (HPLC)≥94.0%
CommentSpecification differs for U.S. and non-U.S. material where indicated
Optical Rotation+23° to +24° (c=1 in 1M HCl :Ethanol 1:2 (non-U.S. specification)
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Using video intensification fluorescence microscopy and tetramethylrhodamine (Rho)-labeled 3, 3', 5-triiodo-L-thyronine (T3),the uptake of T3 by cultured mouse fibroblasts was studied. The binding of 3, 3', 5-triiodo-L-thyronine (T3) to GH3 rat pituitary tumor cells was studied at 15 degrees C and was shown to be saturable, reversible, and stereospecific. A fluorescent derivative of the thyroid hormone 3,3'-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. 3,3?,5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Using video intensification fluorescence microscopy and tetramethylrhodamine (Rho)-labeled 3, 3′, 5-triiodo-L-thyronine (T3),the uptake of T3 by cultured mouse fibroblasts was studied. The binding of 3, 3′, 5-triiodo-L-thyronine (T3) to GH3 rat pituitary tumor cells was studied at 15 degrees C and was shown to be saturable, reversible, and stereospecific. A fluorescent derivative of the thyroid hormone 3,3′-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. 3,3′,5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent.
Solubility
Insoluble in water, ethanol and propylene glycol. Soluble in dilute alkalies.
Notes
Light Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, Strong bases, light.
Using video intensification fluorescence microscopy and tetramethylrhodamine (Rho)-labeled 3, 3′, 5-triiodo-L-thyronine (T3),the uptake of T3 by cultured mouse fibroblasts was studied. The binding of 3, 3′, 5-triiodo-L-thyronine (T3) to GH3 rat pituitary tumor cells was studied at 15 degrees C and was shown to be saturable, reversible, and stereospecific. A fluorescent derivative of the thyroid hormone 3,3′-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. 3,3′,5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent.
Solubility
Insoluble in water, ethanol and propylene glycol. Soluble in dilute alkalies.
Notes
Light Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, Strong bases, light.
RUO – Research Use Only
General References:
- R Horiuchi,; M L Johnson,; M C Willingham,; I Pastan,; S Cheng. Affinity labeling of the plasma membrane 3,3',5-triiodo-L-thyronine receptor in GH3 cells. PNAS. 1982 , 79(18),5527-5531.
- Jianxun Lei,; Cary N. Mariash.; David H. Ingbar. 3,3',5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent . Journal of Biological Chemistry. 2004 , 279 , 47589-47600..