Vancomycin hydrochloride, Molecular Biology Grade

Name: Vancomycin hydrochloride, Molecular Biology Grade
SKU: J62790.06

Vancomycin hydrochloride (vancomycin HCl, CAS # 1404-93-9) is the hydrochloride salt of the bactericidal agent, vancomycin. | CAS: 1404-93-9 | C66H76Cl3N9O24 | 1485.72 g/mol

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Catalog number J62790.06

also known as J62790-06

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5 g

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Chemical Identifiers

CAS1404-93-9

IUPAC Name48-({3-[(4-amino-5-hydroxy-4,6-dimethyloxan-2-yl)oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl}oxy)-22-(carbamoylmethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[4-methyl-2-(methylamino)pentanamido]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2³,⁶.2¹⁴,¹⁷.1⁸,¹².1²⁹,³³.0¹⁰,²⁵.0³⁴,³⁹]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid hydrochloride

Molecular FormulaC66H76Cl3N9O24

InChI KeyLCTORFDMHNKUSG-UHFFFAOYNA-N

SMILESCl.CNC(CC(C)C)C(=O)NC1C(O)C2=CC(Cl)=C(OC3=CC4=CC(OC5=C(Cl)C=C(C=C5)C(O)C5NC(=O)C(NC(=O)C4NC(=O)C(CC(N)=O)NC1=O)C1=CC(=C(O)C=C1)C1=C(O)C=C(O)C=C1C(NC5=O)C(O)=O)=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1)C=C2

Specifications

Specification Sheet

Appearance (Color)White to tan to brown

FormFree-flowing powder

Assay (HPLC)Vancomycin B: ≥85.0%

Heavy Metals≤30 ppm

Water Content (Karl Fischer Titration)≤5.0%

Inhibits bacterial mucopeptide synthesis.Vancomycin hydrochloride is used as an antiviral and anti bacterial. binds to bacterial cell wall. It exhibits potent activity against Gram positive bacteria and is highly effective against MRSA.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Vancomycin hydrochloride is a glycopeptide antibiotic that prevents cell wall synthesis
Originally obtained from the bacterial strain Streptomyces Orientalis
Vancomycin binds to D-alanyl-D-alanine motifs in cell wall precursors and leads to cell death
It is active against some penicillin-resistant bacteria

Application

Vancomycin hydrochloride is intended for use in the research of infections and for antibiotic resistance testing

RUO – Research Use Only

General References:

Yang, Z.; Liu, J.; Gao, J.; Chen, S.; Huang, G. Chitosan coated vancomycin hydrochloride liposomes: Characterizations and evaluation. Int. J. Pharm. 2015, 495 (1), 508-515.
Mori, M.; Rossi, S.; Bonferoni, M. C.; Ferrari, F.; Sandri, G.; Riva, F.; Fantec, C. D.; Perotti, C.; Caramella, C. Calcium alginate particles for the combined delivery of platelet lysate and vancomycin hydrochloride in chronic skin ulcers. Int. J. Pharm. 2014, 461 (1-2), 505-513.