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4-Nitrophenyl acetate, 97%
4-Nitrophenyl acetate, 97%
4-Nitrophenyl acetate, 97%
Thermo Scientific Chemicals

4-Nitrophenyl acetate, 97%

CAS: 830-03-5 | C8H7NO4 | 181.15 g/mol
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Catalog number L00314.09
also known as L00314-09
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10 g
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Chemical Identifiers
CAS830-03-5
IUPAC Name4-nitrophenyl acetate
Molecular FormulaC8H7NO4
InChI KeyQAUUDNIGJSLPSX-UHFFFAOYSA-N
SMILESCC(=O)OC1=CC=C(C=C1)[N+]([O-])=O
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SpecificationsSpecification SheetSpecification Sheet
Identification (FTIR)Conforms
FormCrystals or powder or crystalline powder or fused solid
Assay (GC)≥96.0%
Appearance (Color)White to pale cream to cream to yellow to pale brown
4-Nitrophenyl acetate is used with iodoacetic acid for reductive cleavage of methionine-containing peptides. It is also used as a substrate that has been used in assays for esterase and lipase activity. Inorganic complexes have been evaluated for their methanolysis or hydrolysis activity using p-nitrophenyl acetate.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-Nitrophenyl acetate is used with iodoacetic acid for reductive cleavage of methionine-containing peptides. It is also used as a substrate that has been used in assays for esterase and lipase activity. Inorganic complexes have been evaluated for their methanolysis or hydrolysis activity using p-nitrophenyl acetate.

Solubility
Insoluble in water.

Notes
Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
RUO – Research Use Only

General References:

  1. John C. Hogan.; Richard D. Gandour. Fingerprinting a transition-structure guest by a building-block approach with an incremental series of catalytic hosts. Structural requirements for glyme and .alpha.,. μ. -dimethoxyalkane catalyses in N-methylbutylaminolysis and butylaminolysis of 4-nitrophenyl acetate in chlorobenzene. J. Org. Chem. 1992, 57, (1), 55-61.
  2. Ik-Hwan Um.; Gwang-Ju Lee.; Hye-Won Yoon.; Dong-Sook Kwon. Solvent effect on rate for anionic nucleophilic substitution reaction of 4-nitrophenyl acetate in aqueous acetonitrile. Tetrahedron Letters. 1992, 33, (15), 2023-2026.
  3. Reagent for the N-acylation of amines, e.g. basic amino acids: Can. J. Chem., 43, 991 (1965); 46, 1047 (1968).