2,2-Difluorosuccinic acid, 94%

Name: 2,2-Difluorosuccinic acid, 94%
SKU: L00773.03

CAS: 665-31-6 | C4H4F2O4 | 154.07 g/mol

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Catalog number L00773.03

also known as L00773-03

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Chemical Identifiers

CAS665-31-6

IUPAC Name2,2-difluorobutanedioic acid

Molecular FormulaC4H4F2O4

InChI KeyZYLFHISLYSHWRH-UHFFFAOYSA-N

SMILESOC(=O)CC(F)(F)C(O)=O

Specifications

Specification Sheet

Appearance (Color)White to cream to brown

FormCrystals or powder or crystalline powder or granules

Assay (Aqueous acid-base Titration)≥92.0 to ≤108.0%

Melting Point (clear melt)134.0-146.0°C

2,2-Difluorosuccinic acid is used in the preparation of fluorofumaric acid. It is also used in enolate alkylation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2,2-Difluorosuccinic acid is used in the preparation of fluorofumaric acid. It is also used in enolate alkylation.

Solubility
Soluble in water.

Notes
Store in a cool place. Incompatible with strong oxidizing agents, strong acids, and strong bases.

RUO – Research Use Only

General References:

Risley, J. M.; Kastanis, J. P.; Young, A. M. Determination of the second-order 1H NMR parameters for the aromatic protons in 4-fluoroaniline and application to the analysis of the 1H NMR spectra for the aromatic protons in N4-(4'-fluorophenyl)succinamic acid and in N4-(4'-fluorophenyl)-3,3-difluorosuccinamic acid. J. Fluorine Chem. 2011, 132 (4), 269-275.
Hagan, D. O. Organofluorine Chemistry: Synthesis and Conformation of Vicinal Fluoromethylene Motifs. J. Org. Chem. 2012, 77 (8), 3689-3699.
Perrin, C. L.; Karri, P.; Moore, C.; Rheingold, A. L. Hydrogen-Bond Symmetry in Difluoromaleate Monoanion. J. Am. Chem. Soc. 2012, 134 (18), 7766-7772.
McAlpine, I.; Tran-Dubé, M.; Wang, F.: Scales, S.; Matthews, J.; Collins, M. R.; Nair, S. K.; Nguyen, M.; Bian, J.; Alsina, L.M.; Sun, J.; Zhong, J.; Warmus, J. S.; O’Neill, B. T. Synthesis of Small 3-Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry. J. Org. Chem. 2015, 80 (14), 7266-7274.