Mitomycin C, contains 2 mg Mitomycin C and 48 mg NaCl

Mitomycin C, CAS # 50-07-7, is a methylazirinopyrroloindoledione complex isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. It is a versatile and potent compound with antibiotic activity and may have potential therapeutic value in the treatment of cancer. | CAS: 50-07-7 | C₁₅H₁₈N₄O₅ | 334.32 g/mol

產品號碼	Quantity
226940020	2 mg

產品號碼 226940020

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CAS50-07-7

IUPAC Name[(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.0²,⁷.0⁴,⁶]trideca-1(9),11-dien-8-yl]methyl carbamate

Molecular FormulaC15H18N4O5

InChI KeyNWIBSHFKIJFRCO-WUDYKRTCSA-N

SMILESCO[C@]12[C@H]3N[C@H]3CN1C1=C([C@H]2COC(N)=O)C(=O)C(N)=C(C)C1=O

Appearance (Color)Grey to blue

Appearance (Form)Powder

HPLC>=99 % with regard to the non-formulated material

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

Mitomycin C is a water soluble, blue-violet crystalline powder, unstable in light and acidic conditions, but may be stably stored at 2-8°c
Bio-reduced mitomycin C generates oxygen radicals, alkylates DNA, and produces inter-strand DNA cross-links, thereby inhibiting DNA synthesis

Applications

Mitomycin C is preferentially toxic to hypoxic cells that are resistant to cancer therapy, and is therefore used to study its potential therapeutic effect on advanced stages of cancer
At high concentrations, mitomycin C inhibits RNA and protein synthesis and demonstrates strong antibiotic properties towards both Gram-positive and Gram-negative bacteria

RUO – Research Use Only

Literature References: Verweij, J.; Pinedo, H. M. Mitomycin C: mechanism of action, usefulness and limitations. Anticancer Drugs. 1990, 1(1), 5-13.Tomasz, M.; Mitomycin, C. Small, fast and deadly (but very selective). Chem Biol. 1995, 2(9), 575-9. Teus, M. A.; de Benito-Llopis, L.; Alió, J.L. Mitomycin C in corneal refractive surgery. Surv Ophthalmol. 2009 Jul-Aug;54(4):487-502.