Prednisolone, 99%, Thermo Scientific Chemicals

Name: Prednisolone, 99%, Thermo Scientific Chemicals
SKU: 449470010

Prednisolone, or metacortandralone, CAS # 50-24-8, is a synthetic glucocorticoid.

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產品號碼	Quantity	Packaging
449470010	1g	Glass bottle
449470050	5g	Glass bottle
449470250	25g	Glass Bottle

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產品號碼 449470010

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化學識別

CAS50-24-8

IUPAC Name(1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one

Molecular FormulaC21H28O5

InChI KeyOIGNJSKKLXVSLS-VWUMJDOOSA-N

SMILESC[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO

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規格

規格表

HPLC>=98.5 %

Appearance (Color)White to off-white

Specific optical rotation+113° to +119° (20°C, 589 nm) (c=1, ethanol)

Infrared spectrumConforms

Loss on drying=<1 %

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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Prednisolone is a derivative of prednisone with an oxo to beta-hydroxy reduction at position 11

• Prednisolone binds cell surface receptors and is transported to the nucleus, where it binds certain nuclear receptors responsible for transcription of proinflammatory cytokines

Applications

• Prednisolone can be used for laboratory research on tumor growth and prevention

• Prednisolone may also be used for developmental and endocrine research, in vivo or in vitro

RUO – Research Use Only

Literature References

Waldrop, M.A.; Karingada, C.; Storey, M.A.; Powers, B.; Lammarino, M.A.; Miller, N.F.; Alfano, L.N.; Noritz, G.; Rossman, I.; Ginsberg, M.; Mosher, K.A., Broomall, E.; Goldstein, J.; Bass, N.; Lowes, L.P.; Tsao, C.Y.; Mendell, J.R.; Connolly, A.M. Gene Therapy for Spinal Muscular Atrophy: Safety and Early Outcomes. Pediatrics. 2020, 146(3), e20200729.

Koumpa, F.S.; Forde, C.T.; Manjaly, J.G. Sudden irreversible hearing loss post COVID-19. BMJ Case Rep. 2020, 13(11), e238419.