Trimethoprim, 98%

Trimethoprim, CAS # 738-70-5, is a trimethoxybenzyl-pyrimidine used as an antimicrobial.

產品號碼	Quantity
455121000	100g

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產品號碼 455121000

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CAS738-70-5

IUPAC Name5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine

Molecular FormulaC14H18N4O3

InChI KeyIEDVJHCEMCRBQM-UHFFFAOYSA-N

SMILESCOC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC

Appearance (Form)Powder

Melting point199°C to 203°C

HPLC>=97.5 %

Infrared spectrumConforms

Loss on drying=<0.5 % (105°C, 4 h)

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Trimethoprim is a synthetic pyrimidine analog that binds dihydrofolate-reductase and inhibits the synthesis of folic acid; when paired with sulfamethoxazole, its activity is enhanced • Trimethoprim has antibacterial and antiprotozoal properties

Applications

• Trimethoprim inhibits the conversion of para-aminobenzoic acid (PABA) to folic acid near the end of the synthesis pathway and can be used to study related effects

• Trimethoprim has been radiolabeled and used to trace routes of infection, and it also has been used experimentally as a fluorescent labeler to quantify dihydrofolate-reductase expression

RUO – Research Use Only

Literature References

De Smet, J.; Croubels, S.; De Backer, P.; Devreese, M. Effect of administration route and dose alteration on sulfadiazine-trimethoprim plasma and intestinal concentrations in pigs. Int J Antimicrob Agents. 2017, 50(6), 707-714.

Ma, R.; Wang, Y.; Zou, X.; Hu, K.; Sun, B.; Fang, W.; Fu G, Yang X. Pharmacokinetics of sulfamethoxazole and trimethoprim in Pacific white shrimp, Litopenaeus vannamei, after oral administration of single-dose and multiple-dose. Environ Toxicol Pharmacol. 2017, 52, 90-98.