Ketoconazole, 98%

Name: Ketoconazole, 98%
SKU: 455470050

Ketoconazole, CAS # 65277-42-1, is a synthetic, broad-spectrum antifungal agent with the ability to inhibit a variety of fungal infections. | CAS: 65277-42-1 | C₂₆H₂₈Cl₂N₄O₄ | 531.44 g/mol

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產品號碼 455470050

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化學識別

CAS65277-42-1

IUPAC Name1-[4-(4-{[(2S,4R)-2-(2,4-dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one

Molecular FormulaC26H28Cl2N4O4

InChI KeyXMAYWYJOQHXEEK-ZEQKJWHPSA-N

SMILESCC(=O)N1CCN(CC1)C1=CC=C(OC[C@@H]2CO[C@](CN3C=CN=C3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1

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規格

規格表

Appearance (Form)Powder

HPLC>=97.5 %

Infrared spectrumConforms

Appearance (Color)White to light brown

Melting point148°C to 152°C

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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Ketoconazole is an imidazole antifungal agent
It functions by inhibiting synthesis of ergosterol, which is the fungal equivalent of cholesterol

Applications

Ketoconazole shows fungicide activity against a variety of yeast infections
It is an inhibitor of CYP3A4, which is necessary for the conversion of lanosterol to ergosterol
It increases fungal cellular permeability
It also inhibits endogenous respiration by disrupting membrane phospholipids
Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone

RUO – Research Use Only

General References:

Takano, M.; Hasegawa, R.; Fukuda, T.; Yumoto, R.; Nagai, J.; Murakami, T. Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells. European Journal of Pharmacology.1998, 358 (3), 289-294.
Goeders, N. E.; Peltier, R. L.; Guerin, G. F. Ketoconazole reduces low dose cocaine self-administration in rats. Drug and Alcohol Dependence.1998, 53 (1), 67-77.