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Thermo Scientific Chemicals
Rifampin, 95%
Rifampin (rifampicin), CAS # 13292-46-1, is a synthetic rifamycin antibiotic that works by inhibiting RNA and DNA synthesis and exhibits activity against the tuberculosis microbe.
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| 產品號碼 | Quantity |
|---|---|
| 455620010 | 1 g |
| 455620050 | 5 g |
| 455620250 | 25 g |
化學識別
CAS13292-46-1
IUPAC Name2,15,17,29-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{[(4-methylpiperazin-1-yl)amino]methylidene}-6,23,27-trioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1⁴,⁷.0⁵,²⁸]triaconta-1,3,5(28),9,19,21,25(29)-heptaen-13-yl acetate
Molecular FormulaC43H58N4O12
InChI KeyFZYOVNIOYYPUPY-UHFFFAOYNA-N
SMILESCOC1C=COC2(C)OC3=C(C)C(O)=C4C(O)=C(NC(=O)C(C)=CC=CC(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C(=CNN1CCN(C)CC1)C(=O)C4=C3C2=O
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規格
規格表
規格表Appearance (Form)Powder
Appearance (Color)Light orange to red-brown
HPLC>=94 %
Infrared spectrumConforms
Loss on drying=<2 % (100 mg, 60°C, 4 h) (vacuum)
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Rifampin is a rifamycin class antibiotic synthesized to resemble the compound isolated from Amycolatopsis rifamycinica
Applications
• Rifampin can be used as a bacteriostatic that prevents RNA and DNA synthesis, particularly in mycobacteria
• It may also act as an antineoplastic, a neuroprotective, and inhibitor of angiogenesis
RUO – Research Use Only
Literature References
Tarakji, K.G.; Mittal, S.; Kennergren, C.; Corey, R.; Poole, J.E.; Schloss, E.; Gallastegui, J.; Pickett, R.A.; Evonich, R.; Philippon, F.; McComb, J.M., Roark, S.F.; Sorrentino, D.; Sholevar, D.; Cronin, E.; Berman, B., Riggio, D.; Biffi, M.; Khan, H.; Silver, M.T.; Collier, J.; Eldadah, Z.; Wright, D.J.; Lande, J.D.; Lexcen, D.R.; Cheng, A.; Wilkoff, B.L. WRAP-IT Investigators. Antibacterial Envelope to Prevent Cardiac Implantable Device Infection. N Engl J Med. 2019, 380(20), 1895-1905.
Swindells, S.; Ramchandani, R.; Gupta, A.; Benson, C.A.; Leon-Cruz, J.; Mwelase, N.; Jean Juste, M.A.; Lama, J.R.; Valencia, J.; Omoz-Oarhe, A.; Supparatpinyo, K.; Masheto, G.; Mohapi L, da Silva Escada, R.O.; Mawlana, S.; Banda, P.; Severe, P.; Hakim, J.; Kanyama, C.; Langat, D.; Moran, L.; Andersen, J.; Fletcher, C.V.; Nuermberger, E.; Chaisson, R.E., BRIEF TB/A5279 Study Team. One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis. N Engl J Med. 2019, 380(11), 1001-1011.