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Thermo Scientific Chemicals
6-Fluoro-2-methylquinoline, 98+%
CAS: 1128-61-6 | C10H8FN | 161.179 g/mol
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化學識別
CAS1128-61-6
IUPAC Name6-fluoro-2-methylquinoline
Molecular FormulaC10H8FN
InChI KeyGPIARMSVZOEZCV-UHFFFAOYSA-N
SMILESCC1=CC=C2C=C(F)C=CC2=N1
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規格
規格表
規格表Appearance (Color)White to pale cream to pale brown to gray
FormCrystals or powder or crystalline powder
Assay (GC)≥98.0%
Identification (FTIR)Conforms
Melting Point (clear melt)49.0-55.0?C
Metal-free transfer hydrogenation of 6-fluoro-2-methylquinoline by employing several chiral Bronsted acid catalysts was carried out in combination with dihydropyridines as the hydride source in asymmetric metal-free synthesis of fluoroquinolones by organocatalytic hydrogenation. Hydrogenation product of 6-fluoro-2-methylquinoline is the key intermediate of the antibacterial agent.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Metal-free transfer hydrogenation of 6-fluoro-2-methylquinoline by employing several chiral Brønsted acid catalysts was carried out in combination with dihydropyridines as the hydride source in asymmetric metal-free synthesis of fluoroquinolones by organocatalytic hydrogenation. Hydrogenation product of 6-fluoro-2-methylquinoline is the key intermediate of the antibacterial agent.
Solubility
Soluble in Chloroform.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
Metal-free transfer hydrogenation of 6-fluoro-2-methylquinoline by employing several chiral Brønsted acid catalysts was carried out in combination with dihydropyridines as the hydride source in asymmetric metal-free synthesis of fluoroquinolones by organocatalytic hydrogenation. Hydrogenation product of 6-fluoro-2-methylquinoline is the key intermediate of the antibacterial agent.
Solubility
Soluble in Chloroform.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
RUO – Research Use Only
General References:
- Magnus Rueping,; Mirjam Stoeckel,; Erli Sugiono,; Thomas Theissmann. Asymmetric metal-free synthesis of fluoroquinolones by organocatalytic hydrogenation. Tetrahedron. 2010 , 6633,6565-6568.
- Nadia M. Ahmad,; Jie Jack Li. Palladium in Quinoline Synthesis. Advances in Heterocyclic Chemistry. 2003, 841-30.