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Thermo Scientific Chemicals
4,4'-Dimethoxytrityl chloride, 97%
CAS: 40615-36-9 | C21H19ClO2 | 338.83 g/mol
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化學識別
CAS40615-36-9
IUPAC Name1-[chloro(4-methoxyphenyl)phenylmethyl]-4-methoxybenzene
Molecular FormulaC21H19ClO2
InChI KeyJBWYRBLDOOOJEU-UHFFFAOYSA-N
SMILESCOC1=CC=C(C=C1)C(Cl)(C1=CC=CC=C1)C1=CC=C(OC)C=C1
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規格
規格表
規格表Appearance (Color)Pale pink to orange
Assay (Titration ex Chloride)≥96.0 to ≤104.0%
FormPowder
Assay (HPLC)≥96.0%
4,4'-Dimethoxytrityl chloride is used as a protective reagent for oligonucleotide synthesis. It is used for selective protection and deprotection procedures for thiol and hydroxy groups in nucleoside derivatives.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
4,4′-Dimethoxytrityl chloride is used as a protective reagent for oligonucleotide synthesis. It is used for selective protection and deprotection procedures for thiol and hydroxy groups in nucleoside derivatives.
Solubility
Soluble in chloroform and methanol. Partially soluble in water
Notes
Moisture sensitive, hygroscopic. Incompatible with strong oxidizing agents.
4,4′-Dimethoxytrityl chloride is used as a protective reagent for oligonucleotide synthesis. It is used for selective protection and deprotection procedures for thiol and hydroxy groups in nucleoside derivatives.
Solubility
Soluble in chloroform and methanol. Partially soluble in water
Notes
Moisture sensitive, hygroscopic. Incompatible with strong oxidizing agents.
RUO – Research Use Only
General References:
- Ingale, S. A.; Leonard, P.; Tran, Q. N.; Seela, F. Duplex DNA and DNA-RNA Hybrids with Parallel Strand Orientation: 2'-Deoxy-2'-fluoroisocytidine, 2'-Deoxy-2'-fluoroisoguanosine, and Canonical Nucleosides with 2'-Fluoro Substituents Cause Unexpected Changes on the Double Helix Stability. J. Org. Chem. 2015, 80 (6), 3124-3138.
- Vemekar, S. K. V.; Qiu, L.; Zhang, J.; Kankanala, J.; Li, H.; Geraghty, R. J.; Wang, Z. 5'-Silylated 3'-1,2,3-triazolyl Thymidine Analogues as Inhibitors of West Nile Virus and Dengue Virus. J. Med. Chem. 2015, 58 (9), 4016-4028.