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Thermo Scientific Chemicals
1-Phenyl-3-pyrazolidinone, 97%
CAS: 92-43-3 | C9H10N2O | 162.192 g/mol
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化學識別
CAS92-43-3
IUPAC Name1-phenylpyrazolidin-3-one
Molecular FormulaC9H10N2O
InChI KeyCMCWWLVWPDLCRM-UHFFFAOYSA-N
SMILESO=C1CCN(N1)C1=CC=CC=C1
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規格
規格表
規格表Appearance (Color)White to cream to pale brown
FormCrystals or powder or crystalline powder
Assay (GC)≥96.0%
Melting Point (clear melt)115.5-124.5?C
Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound. Phenidone has been shown to block neurotoxicity induced by kainate, and weakens oxidative stress induced by lipopolysaccharide.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound. Phenidone has been shown to block neurotoxicity induced by kainate, and weakens oxidative stress induced by lipopolysaccharide.
Solubility
Soluble in water (1:10 hot), methanol (0.1 mg/mL), DMSO (75 mg/mL), and ethanol.
Notes
Store in cool place. Keep away from oxidizing agents.
Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound. Phenidone has been shown to block neurotoxicity induced by kainate, and weakens oxidative stress induced by lipopolysaccharide.
Solubility
Soluble in water (1:10 hot), methanol (0.1 mg/mL), DMSO (75 mg/mL), and ethanol.
Notes
Store in cool place. Keep away from oxidizing agents.
RUO – Research Use Only
General References:
- Dennis J. Hlasta.; Francis B. Casey.; Edward W. Ferguson.; Sally J. Gangell.; Martha R. Heimann.; Edward P. Jaeger.; Rudolph K. Kullnig.; Robert J. Gordon. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J. Med. Chem. 1991, 34 (5),1560-1570.
- Hong-Jun Wang.; Jeffrey Keilman.; Chittari Pabba.; Zhen-Jia Chen.; Brian T. Gregg. Microwave-assisted cross-coupling of 3-chloro-2-pyrazolines and 3-chloro-1-phenyl-1,4,5,6-tetrahydropyridazine with aryl boronic acids. Tetrahedron Lett. 2005, 46 (15),2631-2634.