Search
項目搜尋
結構搜尋
Thermo Scientific Chemicals
Isonipecotamide, 98%
CAS: 39546-32-2 | C6H12N2O | 128.18 g/mol
Have Questions?
變更視圖
化學識別
CAS39546-32-2
IUPAC Namepiperidine-4-carboxamide
Molecular FormulaC6H12N2O
InChI KeyDPBWFNDFMCCGGJ-UHFFFAOYSA-N
SMILESNC(=O)C1CCNCC1
檢視更多
規格
規格表
規格表Appearance (Color)White to pale yellow
FormPowder or crystalline powder
Assay (Non-aqueous acid-base Titration)≥97.5 to ≤102.5% (Dry wt. basis)
Identification (FTIR)Conforms
Water Content (Karl Fischer Titration)≤2.0%
檢視更多
Isonipecotamide is used as a reactant for the preparation of Survival motor neuron (SMN) protein modulators, orally available naphthyridine protein kinase D inhibitors and heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase. It is also used to prepare phosphodiesterase 5 inhibitors. It is also used as a reactant for identification of small molecular inhibitors of importin-beta mediated nuclear import. It is also used as a fluorenylmethyloxycarbonyl - deprotection agent in organic synthesis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Isonipecotamide is used as a reactant for the preparation of Survival motor neuron (SMN) protein modulators, orally available naphthyridine protein kinase D inhibitors and heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase. It is also used to prepare phosphodiesterase 5 inhibitors. It is also used as a reactant for identification of small molecular inhibitors of importin-beta mediated nuclear import. It is also used as a fluorenylmethyloxycarbonyl - deprotection agent in organic synthesis.
Solubility
Soluble in water.
Notes
Moisture sensitive. Hygroscopic. Incompatible with strong oxidizing agents.
Isonipecotamide is used as a reactant for the preparation of Survival motor neuron (SMN) protein modulators, orally available naphthyridine protein kinase D inhibitors and heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase. It is also used to prepare phosphodiesterase 5 inhibitors. It is also used as a reactant for identification of small molecular inhibitors of importin-beta mediated nuclear import. It is also used as a fluorenylmethyloxycarbonyl - deprotection agent in organic synthesis.
Solubility
Soluble in water.
Notes
Moisture sensitive. Hygroscopic. Incompatible with strong oxidizing agents.
RUO – Research Use Only
General References:
- de Candia, M.; Marini, E.; Zaetta, G.; Cellamare, S.; Di Stilo, A.; Altomare, C. D. New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity. Eur. J. Pharm. Sci. 2015, 72, 69-80.
- Chandrashekhara, K. G.; Gopalakrishna, B. N.; Nagaraj, P. Spectrophotometric determination of chromium by using sulphanilic acid and N, N-dimethylaniline. Indian J. Chem. Technol. 2015, 22 (1-2), 78-81.