Methyltriphenylphosphonium bromide, 98+%

Name: Methyltriphenylphosphonium bromide, 98+%
SKU: A15878.18

CAS: 1779-49-3 | C19H18BrP | 357.23 g/mol

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產品號碼 A15878.18

亦稱為 A15878-18

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化學識別

CAS1779-49-3

IUPAC Namemethyltriphenylphosphanium bromide

Molecular FormulaC19H18BrP

InChI KeyLSEFCHWGJNHZNT-UHFFFAOYSA-M

SMILES[Br-].C[P+](C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1

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規格

規格表

Appearance (Color)White

FormCrystals or powder or crystalline powder or granules

Assay (Titration ex Bromide)≥98.0 to ≤102.0%

Identification (FTIR)Conforms

Melting Point (clear melt)229-238°C

Methyltriphenylphosphonium bromide is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. It is a lipophilic molecule and used to deliver molecules to specific cell components. Further, it acts as an antineoplastic agent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Methyltriphenylphosphonium bromide is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. It is a lipophilic molecule and used to deliver molecules to specific cell components. Further, it acts as an antineoplastic agent.

Solubility
Soluble in water.

Notes
Hygroscopic. Incompatible with strong oxidizing agents.

RUO – Research Use Only

General References:

Precursor of Wittig ylide for methylenation of carbonyl compounds (see Appendix 1). See, e.g.: Org. Synth. Coll., 5, 751 (1973). A simplified procedure using K₂CO₃ in triglyme has been reported: Synth. Commun., 22, 513 (1992).
Where the ylide is insufficiently reactive, a further proton can be removed by s-BuLi or t-BuLi, and the resulting lithio ylide reacted with hindered ketones such as fenchone: J. Am. Chem. Soc., 104, 4724 (1982). Reaction of the lithio ylide with an epoxide generates a new ylide, with which Wittig olefination of aldehydes gives trans-homoallylic alcohols (same ref.):
Aissaoui, T.; AlNashef, I. M.; Hayyan, M.; Hashim, M. A. Neoteric FT-IR investigation on the functional groups of phosphonium-based deep eutectic solvents. Spectrochim. Acta Mol. Biomol. Spectrosc. 2015, 149, 588-591.
Chou, Y. H.; Takasugi, S.; Goseki, R.; Ishizone, T.; Chen, W. C. Nonvolatile organic field-effect transistor memory devices using polymer electrets with different thiophene chain lengths. Polym. Chem. 2014, 5 (3), 1063-1071.