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Thermo Scientific Chemicals
Nicotinamide, 99%
CAS: 98-92-0 | C6H6N2O | 122.127 g/mol
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化學識別
CAS98-92-0
IUPAC Namepyridine-3-carboxamide
Molecular FormulaC6H6N2O
InChI KeyDFPAKSUCGFBDDF-UHFFFAOYSA-N
SMILESNC(=O)C1=CC=CN=C1
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規格
規格表
規格表Appearance (Color)White to pale cream
FormCrystals or powder or crystalline powder
Assay (Non-aqueous acid-base Titration)≥98.5 to ≤101.5% (dry wt. basis)
CommentMaterial Sourced in UK and US
Melting Point (clear melt)127.0-133.0?C (UK Sourced Material)
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Nicotinamide is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). It may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule. It is an amide derivative of vitamin B3 and a PARP inhibitor.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Nicotinamide is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). It may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule. It is an amide derivative of vitamin B3 and a PARP inhibitor.
Solubility
Soluble in water, ethanol , glycerol, DMSO , methanol, butanol and chloroform. Slightly soluble in ether.
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
Nicotinamide is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). It may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule. It is an amide derivative of vitamin B3 and a PARP inhibitor.
Solubility
Soluble in water, ethanol , glycerol, DMSO , methanol, butanol and chloroform. Slightly soluble in ether.
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
RUO – Research Use Only
General References:
- Kevin J.Bitterman; Rozalyn M.Anderson; Haim Y.Cohen; Magda Latorre-Esteves; David A.Sinclair. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of Yeast Sir2 and Human SIRT1. The Journal of Biological Chemistry. 2002, 277, (47),45099-45107
- Rozalyn M.Anderson; Kevin J.Bitterman; Jason G.Wood; Oliver Medvedik; David A.Sinclair. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Letters to Nature. 2003, 423, 181-185