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Thermo Scientific Chemicals
Quinine hemisulfate monohydrate, 98+%
CAS: 6119-70-6 | C40H54N4O10S | 782.95 g/mol
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CAS6119-70-6
IUPAC Namebis((R)-[(2S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol) sulfuric acid dihydrate
Molecular FormulaC40H54N4O10S
InChI KeyZHNFLHYOFXQIOW-OIGVVMIYNA-N
SMILESO.O.OS(O)(=O)=O.[H][C@@]1(CN2CCC1C[C@@]2([H])[C@H](O)C1=C2C=C(OC)C=CC2=NC=C1)C=C.[H][C@@]1(CN2CCC1C[C@@]2([H])[C@H](O)C1=C2C=C(OC)C=CC2=NC=C1)C=C
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規格
規格表
規格表Assay (Non-aqueous acid-base Titration)≥98.0 to ≤102.0% (Dry wt. basis)
Appearance (Color)White
Water Content (Karl Fischer Titration)4.1 to 5.1% (theory 4.6%)
FormPowder
Optical Rotation-241° ± 5° (c=2 in 0.1M HCl dry weight basis)
Quinine hemisulfate monohydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Quinine hemisulfate monohydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
Solubility
Soluble in a mixture of chloroform and absolute alcohol (2:1).
Notes
Light sensitive. Incompatible with strong oxidizing agents, alkalis, ammonia, strong bases and iodine.
Quinine hemisulfate monohydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
Solubility
Soluble in a mixture of chloroform and absolute alcohol (2:1).
Notes
Light sensitive. Incompatible with strong oxidizing agents, alkalis, ammonia, strong bases and iodine.
RUO – Research Use Only
General References:
- Krzeszewski, M.; Gryko, D. T. x-Shaped Bis (areno)-1, 4-dihydropyrrolo [3, 2-b] pyrroles Generated by Oxidative Aromatic Coupling. J. Org. Chem. 2015, 80 (5), 2893-2899.
- Janiga, A.; Krzeszewski, M.; Gryko, D. T. Diindolo [2, 3-b: 2', 3'-f] pyrrolo [3, 2-b] pyrroles as Electron-Rich, Ladder-Type Fluorophores: Synthesis and Optical Properties. Chem. Asian J. 2015, 10 (1), 212-218.