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Thermo Scientific Chemicals
trans-4-Aminocyclohexanol, 98+%
CAS: 27489-62-9 | C6H13NO | 115.176 g/mol
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化學識別
CAS27489-62-9
IUPAC Name4-aminocyclohexan-1-ol
Molecular FormulaC6H13NO
InChI KeyIMLXLGZJLAOKJN-UHFFFAOYSA-N
SMILESNC1CCC(O)CC1
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規格
規格表
規格表Assay (GC)≥98.0%
Appearance (Color)White to pale cream to pale brown
FormCrystals or powder or crystalline powder or fused solid
Melting Point (clear melt)108.0-115.0?C
trans-4-Aminocyclohexanol is used as raw material in organic synthesis and is an important intermediate in the synthesis of drugs such as Ambroxol hydrochloride. It can react with butyric acid-(2-chloro-ethyl ester) to get butyric acid 4-amino-cyclohexyl ester. This reaction needs catalytic agent Aspergillus niger lipase and solvent 2-methyl-butan-2-ol.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
trans-4-Aminocyclohexanol is used as raw material in organic synthesis and is an important intermediate in the synthesis of drugs such as Ambroxol hydrochloride. It can react with butyric acid-(2-chloro-ethyl ester) to get butyric acid 4-amino-cyclohexyl ester. This reaction needs catalytic agent Aspergillus niger lipase and solvent 2-methyl-butan-2-ol.
Solubility
Soluble in water.
Notes
Air Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
trans-4-Aminocyclohexanol is used as raw material in organic synthesis and is an important intermediate in the synthesis of drugs such as Ambroxol hydrochloride. It can react with butyric acid-(2-chloro-ethyl ester) to get butyric acid 4-amino-cyclohexyl ester. This reaction needs catalytic agent Aspergillus niger lipase and solvent 2-methyl-butan-2-ol.
Solubility
Soluble in water.
Notes
Air Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
RUO – Research Use Only
General References:
- Thomas P. Johnston.; George S. McCaleb.; John A. Montgomery. Synthesis and biologic evaluation of major metabolites of N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea. J. Med. Chem. 1975, 18, (6), 634-637.
- Jie Cheng.; Mark L. Trudell. Synthesis of N-Heteroaryl-7-azabicyclo[2.2.1]heptane Derivatives via Palladium-Bisimidazol-2-ylidene Complex Catalyzed Amination Reactions. Org. Lett.2001, 3, (9), 1371-1374.