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Thermo Scientific Chemicals
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid, 99%
CAS: 17257-71-5 | C10H8F3O3 | 233.17 g/mol
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化學識別
CAS17257-71-5
IUPAC Name(2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
Molecular FormulaC10H8F3O3
InChI KeyJJYKJUXBWFATTE-VIFPVBQESA-M
SMILESCO[C@](C([O-])=O)(C1=CC=CC=C1)C(F)(F)F
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規格
規格表
規格表Identification (FTIR)Conforms
FormFused solid
Assay (GC)≥98.5%
Optical Rotation-72.0 ± 1.0? (C=2 in methanol)
Appearance (Color)White
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(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is used as a chiral derivatizing agent, it reacts with an alcohol or amine of unknown stereochemistry to form an ester or amide. The absolute configuration of the ester or amide is then determined by proton and/or 19F NMR spectroscopy.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is used as a chiral derivatizing agent, it reacts with an alcohol or amine of unknown stereochemistry to form an ester or amide. The absolute configuration of the ester or amide is then determined by proton and/or 19F NMR spectroscopy.
Solubility
Readily soluble in hexane, ether, THF, CH2Cl2, benzene.
Notes
Hygroscopic. Store under inert gas. Store away from oxidizing agents, moisture.
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is used as a chiral derivatizing agent, it reacts with an alcohol or amine of unknown stereochemistry to form an ester or amide. The absolute configuration of the ester or amide is then determined by proton and/or 19F NMR spectroscopy.
Solubility
Readily soluble in hexane, ether, THF, CH2Cl2, benzene.
Notes
Hygroscopic. Store under inert gas. Store away from oxidizing agents, moisture.
RUO – Research Use Only
General References:
- Peter Wasserscheid; Andreas Bösmanna and Carsten Bolm. Synthesis and properties of ionic liquids derived from the ‘chiral pool’. Chem. Commun. 2002, (3), 200-201.
- Dale E. Ward; Chung K. Rhee. A simple method for the microscale preparation of mosher's acid chloride. Tetrahedron Letters. 1991, 49 (32), 7165-7166.