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Thermo Scientific Chemicals
Nalidixic acid, 99%
CAS: 389-08-2 | C12H12N2O3 | 232.239 g/mol
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化學識別
CAS389-08-2
IUPAC Name1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Molecular FormulaC12H12N2O3
InChI KeyMHWLWQUZZRMNGJ-UHFFFAOYSA-N
SMILESCCN1C=C(C(O)=O)C(=O)C2=CC=C(C)N=C12
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規格
規格表
規格表Melting Point (clear melt)224.0-233.0?C
Identification (FTIR)Conforms
Appearance (Color)White to pale cream to pale yellow
FormPowder
Assay (Aqueous acid-base Titration)≥98.5 to ≤101.5%
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This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Suitable for battery materials development.
Applications
Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent. It is also used as an inhibitor of bacterial DNA gyrase. It plays an important role in the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species and Proteus species.
Solubility
Soluble in diethyl ether, acetone, methylene chloride, chloroform and methanol. Insoluble in water.
Notes
Light sensitive and air sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.
Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent. It is also used as an inhibitor of bacterial DNA gyrase. It plays an important role in the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species and Proteus species.
Solubility
Soluble in diethyl ether, acetone, methylene chloride, chloroform and methanol. Insoluble in water.
Notes
Light sensitive and air sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.
RUO – Research Use Only
General References:
- Chintagari, S.; Hung, Y. C.; Hamanaka, D. Resistance of various STEC strains and serogroups to UV radiation and effect of nalidixic acid adaptation. Food Control 2015, 50, 313-319.
- Dwivedi, G. R.; Maurya, A.; Yadav, D. K.; Khan, F.; Darokar, M. P.; Srivastava, S. K. Drug Resistance Reversal Potential of Ursolic Acid Derivatives against Nalidixic Acid- and Multidrug-resistant Escherichia coli. Chem. Biol. Drug Des. 2015, 86 (3), 272-283.