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引用資料與參考文獻 (33)
Invitrogen™
DiFMUP (6,8-Difluoro-4-Methylumbelliferyl Phosphate)
DiFMUP is a fluorinated 4-methylumbelliferyl phosphate (MUP) derivative that has a lower pKa than that of MUP, making DiFMUP an深入閱讀
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| 產品號碼 | Quantity |
|---|---|
| D6567 | 5mg |
| D22065 | 10 x 10mg |
產品號碼 D6567
價格 (TWD)
6,450.00
Online offer
Ends: 31-Dec-2025
9,190.00您節省 2,740.00 (30%)
Each
Quantity:
5mg
價格 (TWD)
6,450.00
Online offer
Ends: 31-Dec-2025
9,190.00您節省 2,740.00 (30%)
Each
DiFMUP is a fluorinated 4-methylumbelliferyl phosphate (MUP) derivative that has a lower pKa than that of MUP, making DiFMUP an excellent substrate for continuously assaying acid phosphatases at low pH. The reaction product of DiFMUP has excitation/emission maxima of ∼358/450 nm. DiFMUP is also available packaged in ten vials of 10 mg each (D-22065).
For Research Use Only. Not for use in diagnostic procedures.
規格
ColorBlue
Excitation/Emission358⁄455
For Use With (Equipment)Microplate Reader
Label or DyeDiFMU
Quantity5mg
Shipping ConditionRoom Temperature
SubstratePhosphatase Substrate
Detection MethodFluorescence
FormPowder
Substrate PropertiesChemical Substrate
Target EnzymePhosphatases
Unit SizeEach
內容物與存放
Store in freezer (-5 to -30°C).
引用資料與參考文獻 (33)
引用資料與參考文獻
Abstract
Surface phosphophilicity of aluminum-containing adjuvants probed by their efficiency for catalyzing the P--O bond cleavage with chromogenic and fluorogenic substrates.
Journal:Anal Biochem
PubMed ID:11476547
'Aluminum-containing adjuvants are widely used in a variety of vaccine products, such as recombinant proteins, virus-like particles, conjugated polysaccharides, and recently DNA vaccines. Aluminum-containing adjuvants are also known to have a high affinity to inorganic phosphate and its mono- or diesters. Since phosphate groups are present in many antigens as
Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP.
Journal:Nat Cell Biol
PubMed ID:15592458
'Integrin-mediated cell adhesion regulates a multitude of cellular responses, including proliferation, survival and cross-talk between different cellular signalling pathways. So far, integrins have been mainly shown to convey permissive signals enabling anchorage-dependent receptor tyrosine kinase signalling. Here we show that a collagen-binding integrin alpha(1)beta(1) functions as a negative regulator of
Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
Journal:Mol Pharmacol
PubMed ID:16717135
'Shp2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene. It is involved in growth factorinduced activation of mitogen-activated protein (MAP) kinases Erk1 and Erk2 (Erk1/2) and has been implicated in the pathogenicity of the oncogenic bacterium Helicobacter pylori. Moreover, gain-of-function Shp2 mutations have been found in
Loss of phosphatase activity in Ptp69D alleles supporting axon guidance defects.
Journal:J Cell Biochem
PubMed ID:16514605
'PTP69D is a receptor protein tyrosine phosphatase that was identified as a key regulator of neuromuscular axon guidance in Drosophila, and has subsequently been shown to play a similar role in the central nervous system and retina. Three Ptp69D alleles with mutations involving catalytically important residues exhibit a high degree
High yield expression of serine/threonine protein phosphatase type 5, and a fluorescent assay suitable for use in the detection of catalytic inhibitors.
Journal:Assay Drug Dev Technol
PubMed ID:17939754
'Protein phosphatase type 5 (PP5) belongs to the PPP family of serine/threonine protein phosphatases and is expressed in most, if not all, human tissues. Although the physiological roles played by PP5 are not yet clear, PP5 is found in association with several proteins that influence intracellular signaling networks initiated by