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Thermo Scientific Chemicals
(S)-(+)-3-Amino-1-Boc-piperidine, 97%
CAS: 625471-18-3 | C10H20N2O2 | 200.28 g/mol
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CAS625471-18-3
規格
規格表
規格表FormLiquid or viscous liquid
Refractive Index1.4710-1.4750 @ 20?C
Appearance (Color)Clear colorless to yellow
Assay (GC)≥96.0%
Optical Rotation+26.5? to +30.5? (c=1 in DMF)
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(S)-(+)-3-Amino-1-Boc-piperidine is used to prepare selective noncovalent inhibitors of the bacterial cysteine protease IdeS. The product obtained by the reductive elimination reaction with ethylglyoxalte is used as a reference compound, which is used to determine the absolute configuration of the two enantiomers.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
(S)-(+)-3-Amino-1-Boc-piperidine is used to prepare selective noncovalent inhibitors of the bacterial cysteine protease IdeS. The product obtained by the reductive elimination reaction with ethylglyoxalte is used as a reference compound, which is used to determine the absolute configuration of the two enantiomers.
Solubility
Soluble in dimethylsulfoxide.
Notes
Air and carbon dioxide sensitive. Incompatible with strong oxidizing agents, strong acids and bases. Store in a cool place.
(S)-(+)-3-Amino-1-Boc-piperidine is used to prepare selective noncovalent inhibitors of the bacterial cysteine protease IdeS. The product obtained by the reductive elimination reaction with ethylglyoxalte is used as a reference compound, which is used to determine the absolute configuration of the two enantiomers.
Solubility
Soluble in dimethylsulfoxide.
Notes
Air and carbon dioxide sensitive. Incompatible with strong oxidizing agents, strong acids and bases. Store in a cool place.
RUO – Research Use Only
General References:
- Berggren, K.; Vindebro, R.; Bergström, C.; Spoerry, C.; Persson, H.; Fex, T.; Kihlberg, J.; Rammingen, U. V. P.; Luthman, K. 3-Aminopiperidine-Based Peptide Analogues as the First Selective Noncovalent Inhibitors of the Bacterial Cysteine Protease IdeS. J. Med. Chem. 2012, 55 (6), 2549-2560.
- Henary, M.; Paranjpe, S.; Owens, E. A. Substituted benzothiazoles: synthesis and medicinal characteristics. Heterocycl. Commun. 2013, 19 (2), 89-99.