5'-O-(tert-Butyldimethylsilyl)thymidine, 97+%, Thermo Scientific Chemicals

產品號碼	Quantity
H52301.03 亦稱為 H52301-03	1 g

產品號碼 H52301.03

亦稱為 H52301-03

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CAS40733-28-6

IUPAC Name1-[(2R,4S,5R)-5-{[(tert-butyldimethylsilyl)oxy]methyl}-4-hydroxyoxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Molecular FormulaC16H28N2O5Si

InChI KeyIJWIJLIIOKZJMS-YNEHKIRRSA-N

SMILESCC1=CN([C@H]2C[C@H](O)[C@@H](CO[Si](C)(C)C(C)(C)C)O2)C(=O)NC1=O

FormPowder

Assay from Supplier's CofA≥97.0%

CommentIdentification by NMR: Conforms

Appearance (Color)White to off-white

Loss on Drying≤1.0%

5'-O-(tert-Butyldimethylsilyl)thymidine is used as pharmaceutical intermediate.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
5′-O-(tert-Butyldimethylsilyl)thymidine is used as pharmaceutical intermediate.

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.

RUO – Research Use Only

General References:

Masayoshi Takase; Masahiko Inouye. Highly efficient recognition of native TpT by artificial ditopic hydrogen-bonding receptors possessing a conformationally well-defined linkage. J. Org. Chem. 2003, 68, (3),1134-1137
Yixin Lu. Recent advances in the stereocontrolled synthesis of antisense phosphorothioates. Mini Reviews in Medicinal Chemistry. 2006, 6, (3),319-330