Search
項目搜尋
結構搜尋
Thermo Scientific Chemicals
3-Methyl-1H-pyrazole-5-carboxylic acid, 97%
CAS: 402-61-9 | C5H6N2O2 | 126.115 g/mol
Have Questions?
變更視圖
化學識別
CAS402-61-9
IUPAC Name5-methyl-1H-pyrazole-3-carboxylic acid
Molecular FormulaC5H6N2O2
InChI KeyWSMQKESQZFQMFW-UHFFFAOYSA-N
SMILESCC1=CC(=NN1)C(O)=O
檢視更多
規格
規格表
規格表Assay (HPLC)>96.0%
3-Methylpyrazole-5-carboxylic acid is a potent and selective D-amino acid oxidase (DAO) (also known as DAAO, DAMOX and OXDA) inhibitor that protects DAO cells from oxidative stress induced by D-Serine. 3-Methylpyrazole-5-carboxylic acid specifically prevents formalin-induced tonic pain.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
3-Methylpyrazole-5-carboxylic acid is a potent and selective D-amino acid oxidase (DAO) (also known as DAAO, DAMOX and OXDA) inhibitor that protects DAO cells from oxidative stress induced by D-Serine. 3-Methylpyrazole-5-carboxylic acid specifically prevents formalin-induced tonic pain.
Solubility
Soluble in dimethyl sulfoxide.
Notes
Store at room temperature. Keep away from oxidizing agents.
3-Methylpyrazole-5-carboxylic acid is a potent and selective D-amino acid oxidase (DAO) (also known as DAAO, DAMOX and OXDA) inhibitor that protects DAO cells from oxidative stress induced by D-Serine. 3-Methylpyrazole-5-carboxylic acid specifically prevents formalin-induced tonic pain.
Solubility
Soluble in dimethyl sulfoxide.
Notes
Store at room temperature. Keep away from oxidizing agents.
RUO – Research Use Only
General References:
- Donald J. P. Pinto.; Michael J. Orwat.; Shuaige Wang.; John M. Fevig.; Mimi L. Quan.; Eugene Amparo.; Joseph Cacciola.; Karen A. Rossi.; Richard S. Alexander.; Angela M. Smallwood.; Joseph M. Luettgen.; Li Liang.; Bruce J. Aungst.; Matthew R. Wright.; Robert M. Knabb.; Pancras C. Wong.; Ruth R. Wexler.; Patrick Y. S. Lam. Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa1.J. Med. Chem. 2001, 44 (4), 566-578.
- James R. Pruitt.; Donald J. P. Pinto.; Robert A. Galemmo, Jr.; Richard S. Alexander.; Karen A. Rossi.; Brian L. Wells.; Spencer Drummond.; Lori L. Bostrom.; Debra Burdick.; Robert Bruckner.; Haiying Chen.; Angela Smallwood.; Pancras C. Wong.; Matthew R. Wright.; Steven Bai.; Joseph M. Luettgen. ;Robert M. Knabb.; Patrick Y. S. Lam.; Ruth R. Wexler. Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor1. J. Med. Chem. 2003, 46 (25),5298-5315 .