Tolfenamic acid, 99+%

Name: Tolfenamic acid, 99+%
SKU: J61256.06

NSAID that activates calcium-activated potassium channels | CAS: 13710-19-5 | C14H12ClNO2 | 261.705 g/mol

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產品號碼 J61256.06

亦稱為 J61256-06

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Quantity:

5 g

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化學識別

CAS13710-19-5

IUPAC Name2-[(4-chloro-3-methylphenyl)amino]benzoic acid

Molecular FormulaC14H12ClNO2

InChI KeyQDNMBJXNLJFNHT-UHFFFAOYSA-N

SMILESCC1=CC(NC2=CC=CC=C2C(O)=O)=CC=C1Cl

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規格

規格表

Thin Layer Chromatography95.0% min.

Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 μM.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in water (slightly), acetone (∼10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (∼10 mg/ml) and ethanol (50 mg/ml).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.

RUO – Research Use Only

General References:

P.J.Pentikainen; P.J.Neuvonen; C.Backman. Human pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent. European Journal of Clinical Pharmacology. 1981, 19,(5), 359-365.
H.Kankaanranta; E.Moilanen. Flufenamic and tolfenamic acids inhibit calcium influx in human polymorphonuclear leukocytes. Molecular Pharmacology. 1995, 47,(5), 1006-1013.