Puromycin dihydrochloride, 98%

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Thermo Scientific Chemicals

Puromycin dihydrochloride, 98%

Name: Puromycin dihydrochloride, 98%
SKU: J61278.MC

Puromycin dihydrochloride hydrate, CAS # 58-58-2, is an aminoglycoside showing antibiotic, anti-neoplastic, and anti-protozoal activities. This compound also has the ability to inhibit protein synthesis. | CAS: 58-58-2 | C22H31Cl2N7O5 | 544.43 g/mol

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產品號碼 J61278.MC

亦稱為 J61278-MC

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100 mg

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化學識別

CAS58-58-2

IUPAC Name(2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)-9H-purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride

Molecular FormulaC22H31Cl2N7O5

InChI KeyMKSVFGKWZLUTTO-MLYJQVMKNA-N

SMILESCl.Cl.COC1=CC=C(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C(N=CN=C23)N(C)C)C=C1

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規格

規格表

Solution TestClear, colorless

Appearance (Color)White to pale cream

FormPowder

Assay (HPLC)≥97.5%

Water Content (Karl Fischer Titration)≤12.0%

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Suitable for battery materials development.

General Information

• Puromycin dihydrochloride hydrate is the hydrochloride salt form of puromycin and is an aminoglycoside with antibiotic activity isolated from the Streptomyces alboniger
• Puromycin dihydrochloride hydrate is a protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3’-terminal ends of aminoacyl-tRNA, inhibiting protein synthesis

Applications

• This compound shows anti-microbial, anti-protozoal, anti-trypanosomal, and anti-neoplastic activities and is also used as an antibiotic in cell culture
• It also reveals anti-tumor activity in studies on brain cancer cells
• This compound has been used to study transcriptional regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation
• It is active against gram-positive microorganisms, less active against acid-fast bacilli and gram-negative microorganisms. Puromycin can prevent growth of bacteria, protozoa, algae, and mammalian cells in in vitro studies.

RUO – Research Use Only

General References:

Rosson, R. A.; Tebo, B. M.; Nealson, K. H. Use of poisons in determination of microbial manganese binding rates in seawater. Appl. Environ. Microbiol. 1984, 47, (7), 740-745.
Nair, V.; Emanuel, D. J.. Synthetic design, stereochemistry, and enzymic activity of a reversed aminoacyl nucleoside: an analog of puromycin. J. Am. Chem. Soc. 1977, 99, (5), 1571-1576.