beta-Nicotinamide adenine dinucleotide reduced disodium salt, 97%

Name: beta-Nicotinamide adenine dinucleotide reduced disodium salt, 97%
SKU: J61638.06

CAS: 606-68-8 | C21H27N7Na2O14P2 | 709.41 g/mol

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5 g

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產品號碼 J61638.06

亦稱為 J61638-06

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化學識別

CAS606-68-8

IUPAC Namedisodium [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl ({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphonate

Molecular FormulaC21H27N7Na2O14P2

InChI KeyQRGNQKGQENGQSE-WUEGHLCSSA-L

SMILES[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O

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規格

規格表

Molar extinction coefficient (molar absorptivity)340nm: ≥6000 L/(mole cm)

FormPowder

Water Content (Karl Fischer Titration)≤8%

Molar extinction coefficient (molar absorptivity)260nm: ≥14000 L/(mole cm)

Appearance (Color)White to yellow

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β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases). As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases). As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Solubility
It is soluble in water.

Notes
Store with desiccant. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature -20°C Light sensitive. Hygroscopic.

RUO – Research Use Only

General References:

Richard P. Ebstein et. al. Are retinoids potential therapeutic agents in disorders of social cognition including autism?. FEBS Letters.2011, 585, (11), 1529-1536.
Xiaoling Li and Nevzat Kazgan. Mammalian sirtuins and energy metabolism. International Journal of Biological Sciences.2011, 7, (5), 575-587.