Search Thermo Fisher Scientific
項目搜尋
結構搜尋Thermo Scientific Chemicals
Oligomycin, Thermo Scientific Chemicals
產品號碼: J61898.MA
10 mg, Each
說明
Inhibits respiration in mitochondria. Also inhibits ATP synthase
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Oligomycin is a macrolide produced by Streptomyces diastatochromogenes that is toxic to other organisms
• Oligomycin blocks oxidative phosphorylation through inhibition of ATP synthase. The compound binds to the proton channel of ATP synthase and blocks mitochondrial proton import, resulting in accumulation of cytoplasmic protons
• Oligomycin also inhibits Na+/K+ exchange through Na+ occlusion within the Na/K-ATPase
• Oligomycin is provided as a mixture of A, B, and C isomers
Application
• Oligomycin inhibits respiration in mitochondria. It also inhibits ATP synthase
• Oligomycin can induce apoptosis in cultured human hepatocarcinoma and other mammalian cells in laboratory settings
RUO – Research Use Only
圖表
文件與下載
證書
依批號或部分批號搜尋
常見問答集 (常見問題)
引用資料與參考文獻
Search citations by name, author, journal title or abstract text