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Thermo Scientific Chemicals
Thapsigargin, 95%
CAS: 67526-95-8 | C34H50O12 | 650.76 g/mol
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CAS67526-95-8
IUPAC Name(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2H,3H,3aH,4H,5H,6H,6aH,7H,8H,9bH-azuleno[4,5-b]furan-7-yl octanoate
Molecular FormulaC34H50O12
InChI KeyIXFPJGBNCFXKPI-FSIHEZPISA-N
SMILESCCCCCCCC(=O)O[C@@H]1[C@@H](OC(=O)C(\C)=C/C)C(C)=C2[C@@H]3OC(=O)[C@@](C)(O)[C@@]3(O)[C@H](C[C@](C)(OC(C)=O)[C@@H]12)OC(=O)CCC
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規格表Thapsigargin- induces down regulation of the EGF receptor is independent of protein kinase C activation. It is also used as an inducer of stored Ca2+ release.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Thapsigargin- induces down regulation of the EGF receptor is independent of protein kinase C activation. It is also used as an inducer of stored Ca2+ release.
Solubility
Soluble in DMSO (20 mg/ml), ethanol (20 mg/ml), and acetone.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C.
Thapsigargin- induces down regulation of the EGF receptor is independent of protein kinase C activation. It is also used as an inducer of stored Ca2+ release.
Solubility
Soluble in DMSO (20 mg/ml), ethanol (20 mg/ml), and acetone.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C.
RUO – Research Use Only
General References:
- Davidson and Varhol. Kinetics of thapsigargin-Ca2+-ATPase (sarcoplasmic reticulum) interaction reveals a two-step binding mechanism and picomolar inhibition. J.Biol.Chem. 1995, 270 (20), 11731-4.
- Treiman et al. A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. TiPS . 1998, 19 (4), 131-5.