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Thermo Scientific Chemicals
Captopril
Orally active inhibitor of angiotensin-converting enzyme | CAS: 62571-86-2 | C9H15NO3S | 217.283 g/mol
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化學識別
CAS62571-86-2
IUPAC Name(2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
Molecular FormulaC9H15NO3S
InChI KeyFAKRSMQSSFJEIM-RQJHMYQMSA-N
SMILESC[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O
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規格
規格表
規格表FormPowder
Assay (HPLC)80.0% min.
Residue on ignition0.2% max
Melting Point104-110?C
Appearance (Color)White to off-white
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Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density. Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density. Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity
Solubility
Soluble in water (160 mg/ml) at 25°C, sesame and corn oils (<1mg/mL) at 25°C, methanol (>100 mg/ml), ethanol (>100 mg/ml), isopropanol (>100 mg/ml), chloroform (>100 mg/ml), and dichloromethane (>100 mg/ml).
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density. Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity
Solubility
Soluble in water (160 mg/ml) at 25°C, sesame and corn oils (<1mg/mL) at 25°C, methanol (>100 mg/ml), ethanol (>100 mg/ml), isopropanol (>100 mg/ml), chloroform (>100 mg/ml), and dichloromethane (>100 mg/ml).
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
RUO – Research Use Only
General References:
- Andrew S Greene; Sandra L Amaral. Microvascular angiogenesis and the renin-angiotensin system. Current Hypertension Reports. 2002, 4 (1), 56-62 .
- N K Hollenberg. Renal implications of angiotensin receptor blockers. American Journal of Hypertension. 2001, 14, 237S-241S.