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Thermo Scientific Chemicals
N,N-Dimethylacetamide dimethyl acetal, tech. 90%, stab.
CAS: 18871-66-4 | C6H15NO2 | 133.191 g/mol
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化學識別
CAS18871-66-4
IUPAC Name(1,1-dimethoxyethyl)dimethylazanium
Molecular FormulaC6H16NO2
InChI KeyFBZVZUSVGKOWHG-UHFFFAOYSA-O
SMILESCOC(C)(OC)[NH+](C)C
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規格
規格表
規格表StabilizerSodium carbonate (Na2CO3): 0.1-0.5% by weight (non-U.S. specification)
Appearance (Color)Clear colorless to yellow
Assay (Non-aqueous acid-base Titration)≥88.0% (non-U.S. specification)
Assay from Suppliers CofA≥88.0% (Proton-NMR, U.S. specification)
CommentSpecification differs for U.S. and non-U.S. material where indicated
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N,N-Dimethylacetamide dimethyl acetal is used as a reagent for the synthesis of amides, diacylamines, and heterocycles, one carbon inserting synthon in preparation of pyrimido[1,2-a][1,3,5]triazin-6-ones. It is used as intermediate in building block.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
N,N-Dimethylacetamide dimethyl acetal is used as a reagent for the synthesis of amides, diacylamines, and heterocycles, one carbon inserting synthon in preparation of pyrimido[1,2-a][1,3,5]triazin-6-ones. It is used as intermediate in building block.
Solubility
Hydrolyzes in water.
Notes
Moisture Sensitive. Store at 2 - 8°C. Incompatible with strong oxidizing agents, Acids.
N,N-Dimethylacetamide dimethyl acetal is used as a reagent for the synthesis of amides, diacylamines, and heterocycles, one carbon inserting synthon in preparation of pyrimido[1,2-a][1,3,5]triazin-6-ones. It is used as intermediate in building block.
Solubility
Hydrolyzes in water.
Notes
Moisture Sensitive. Store at 2 - 8°C. Incompatible with strong oxidizing agents, Acids.
RUO – Research Use Only
General References:
- Richard K. Hill; Raghovan. Soman; Seiji. Sawada. Asymmetric induction in the thermal reactions of allylic alcohols with N,N-dimethylacetamide dimethylacetal and triethyl orthoacetate.J. Org. Chem.1972, 37 (23), 3737-3740.
- Robert G. Salomon, Swadesh R. Raychaudhuri. Convenient preparation of N,N-dimethylacetamide dimethyl acetal.J. Org. Chem.1984, 49 (19), 3659-3660.
- Reacts with 1,2-diols, e.g. sugars, to form 1-(dimethylamino)ethylidene cyclic acetals which can be cleaved with aqueous AcOH, giving the monoacetate of the less hindered OH, thus providing a method for selective monoprotection of the diol: Can. J. Chem., 50, 233 (1972).
- Reacts with active methylene compounds to give the (dimethylamino)ethylidene derivatives: Liebigs Ann. Chem., 641, 1 (1961), compare N,N-Dimethyl formamide dimethyl acetal, A15350.
- For use in the N-acetylation of amides to give diacylamines (imides) in high yield, see: Synthesis, 119 (1980).