4-Hydroxy-1-methylpiperidine, 98%
4-Hydroxy-1-methylpiperidine, 98%
4-Hydroxy-1-methylpiperidine, 98%
4-Hydroxy-1-methylpiperidine, 98%
Thermo Scientific Chemicals

4-Hydroxy-1-methylpiperidine, 98%

CAS: 106-52-5 | C6H13NO | 115.176 g/mol
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產品號碼 L06415.22
亦稱為 L06415-22
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化學識別
CAS106-52-5
IUPAC Name1-methylpiperidin-4-ol
Molecular FormulaC6H13NO
InChI KeyBAUWRHPMUVYFOD-UHFFFAOYSA-N
SMILESCN1CCC(O)CC1
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規格Specification Sheet規格表
Refractive Index1.4760-1.4810 as melt
Appearance (Color)Clear colorless to brown
FormLiquid as melt
Assay (GC)≥97.5%
4-Hydroxy-1-methylpiperidine is used as reactant for optimization of Novobiocin scaffold to product antitumor agents, substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis. It is also used as a reactant in the synthesis of CaMKII, VEGFR and FGFR kinase inhibitors and Phosphoinositide-3-kinase, Protein lysine methyltransferase G9a inhibitors.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-Hydroxy-1-methylpiperidine is used as reactant for optimization of Novobiocin scaffold to product antitumor agents, substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis. It is also used as a reactant in the synthesis of CaMKII, VEGFR and FGFR kinase inhibitors and Phosphoinositide-3-kinase, Protein lysine methyltransferase G9a inhibitors.

Solubility
Soluble in water.

Notes
Hygroscopic. Store under dry inert gas. Store away from moisture and oxidizing agents. Incompatible with water and oxidizing agents. Store at 4°C.
RUO – Research Use Only

General References:

  1. Z. Dega-Szafran; E. Dulewicz; G. Dutkiewicz; Z. Kosturkiewicz; M. Szafran. Two polymorphs of 4-hydroxy-1-methylpiperidine betaine hydrochloride studied by X-ray and DFT methods.Journal of Molecular Structure.2005,751 139-150.
  2. Z. Dega-Szafran; G. Dutkiewicz; Z. Fojud, Z. Kosturkiewicz; M. Szafran. Ring inversion in 4-hydroxy-1-methylpiperidine betaine studied by X-ray, FTIR, 13C CP MAS NMR and DFT calculations.Journal of Molecular Structure.2009,917 76-83.