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Thermo Scientific Chemicals
Chloromethyl chloroformate, 97%
CAS: 22128-62-7 | C2H2Cl2O2 | 128.936 g/mol
| 產品號碼 | Quantity |
|---|---|
| L09527.18 亦稱為 L09527-18 | 50 g |
化學識別
CAS22128-62-7
IUPAC Namechloromethyl carbonochloridate
Molecular FormulaC2H2Cl2O2
InChI KeyJYWJULGYGOLCGW-UHFFFAOYSA-N
SMILESClCOC(Cl)=O
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規格
規格表
規格表FormLiquid or viscous liquid
Refractive Index1.4270-1.4320 @ 20?C
Appearance (Color)Clear colorless
Assay (GC)≥96.0%
Identification (FTIR)Conforms
Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.
Solubility
Slightly miscible with water.
Notes
Incompatible with oxidizing agents and water.
Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.
Solubility
Slightly miscible with water.
Notes
Incompatible with oxidizing agents and water.
RUO – Research Use Only
General References:
- Naganathan, S.; Andersen, D. L.; Andersen, N. G.; Lau, S.; Lohse, A.; Sorensen, M. D. Process Development and Scale-Up of a Benzoxazepine-Containing Kinase Inhibitor. Org. Process Res. Dev. 2015, 19 (7), 721-734.
- Wu, P.; Petersen, M. A.; Cohrt, A. E.; Petersen, R.; Clausen, M. H.; Nielsen, T. E. Reductive Cyclization and Petasis-Like Reaction for the Synthesis of Functionalized γ-Lactams. Eur. J. Org. Chem. 2015, 2015 (11), 2346-2350.