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Thermo Scientific Chemicals
Trimethyl orthoacetate, 98%
CAS: 1445-45-0 | C5H12O3 | 120.148 g/mol
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化學識別
CAS1445-45-0
IUPAC Name1,1,1-trimethoxyethane
Molecular FormulaC5H12O3
InChI KeyHDPNBNXLBDFELL-UHFFFAOYSA-N
SMILESCOC(C)(OC)OC
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規格
規格表
規格表Refractive Index1.3870-1.3910 @ 20?C
Assay (GC)≥97.5%
FormLiquid
Appearance (Color)Clear colorless to pale yellow
Trimethyl orthoacetate is used as a diols can be protected as their 1-methoxyethylidene cyclic acetals (2-methoxy-2-methyl-1,3-dioxolanes) by acid-catalyzed exchange. It is mainly used as the chemical intermediates of the medicine. Some of the other applications includes it is mainly used as chemical intermediate of pharmaceutical and agricultural chemicals, used for compound medical intermediates of vitamin B1, vitamin A1 and sulfanilamide organism, used for dye and spices industry, Medicine, agricultural chemicals, paint additives.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Trimethyl orthoacetate is used as a diols can be protected as their 1-methoxyethylidene cyclic acetals (2-methoxy-2-methyl-1,3-dioxolanes) by acid-catalyzed exchange. It is mainly used as the chemical intermediates of the medicine. Some of the other applications includes it is mainly used as chemical intermediate of pharmaceutical and agricultural chemicals, used for compound medical intermediates of vitamin B1, vitamin A1 and sulfanilamide organism, used for dye and spices industry, Medicine, agricultural chemicals, paint additives.
Solubility
It hydrolyzes in water.
Notes
Moisture Sensitive. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.
Trimethyl orthoacetate is used as a diols can be protected as their 1-methoxyethylidene cyclic acetals (2-methoxy-2-methyl-1,3-dioxolanes) by acid-catalyzed exchange. It is mainly used as the chemical intermediates of the medicine. Some of the other applications includes it is mainly used as chemical intermediate of pharmaceutical and agricultural chemicals, used for compound medical intermediates of vitamin B1, vitamin A1 and sulfanilamide organism, used for dye and spices industry, Medicine, agricultural chemicals, paint additives.
Solubility
It hydrolyzes in water.
Notes
Moisture Sensitive. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.
RUO – Research Use Only
General References:
- HPM Fromageot.; BE Griffin.; CB Reese.; JE Sulston. The synthesis of oligoribonucleotides—III: Monoacrylation of ribonucleosides and derivativesvia orthoester exchange. Tetrahedron. 1967, 23,(5), 2315-2331.
- T Yoshino.; S Imori.; H Togo. Efficient esterification of carboxylic acids and phosphonic acids with trialkyl orthoacetate in ionic liquid. Tetrahedron. 2006, 62,(6), 1309-1317.
- Diols can be protected as their 1-methoxyethylidene cyclic acetals (2-methoxy-2-methyl-1,3-dioxolanes) by acid-catalyzed exchange; see, e.g.: J. Am. Chem. Soc., 95, 278 (1973). See also Triethyl orthoacetate, L06004.