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Thermo Scientific Chemicals
2-Chloro-2,2-difluoroacetophenone, 96%
CAS: 384-67-8 | C8H5ClF2O | 190.574 g/mol
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化學識別
CAS384-67-8
IUPAC Name2-chloro-2,2-difluoro-1-phenylethan-1-one
Molecular FormulaC8H5ClF2O
InChI KeyMNOONJNILVDLSW-UHFFFAOYSA-N
SMILESFC(F)(Cl)C(=O)C1=CC=CC=C1
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規格
規格表
規格表Refractive Index1.4925-1.4985 @ 20?C
Appearance (Color)Clear colorless to yellow to orange
FormLiquid
Assay (GC)≥95.0%
Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.
Solubility
Difficult to mix.
Notes
Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.
Solubility
Difficult to mix.
Notes
Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
RUO – Research Use Only
General References:
- Laijun Zhang.; Ji Zheng.; Jinbo Hu. 2-Chloro-2,2-difluoroacetophenone: A Non-ODS-Based Difluorocarbene Precursor and Its Use in the Difluoromethylation of Phenol Derivatives. J. Org. Chem. 2006, 71, (26), 9845-9848.
- Wei Zhang.; Fei Wang.; Jinbo Hu. N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles. Org. Lett. 2009, 11, (10), 2109-2112.