Fluorescein-ERM (LRRKtide)
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引用資料與參考文獻 (1)

Fluorescein-ERM (LRRKtide)

A fluorescein-labeled peptide substrate based upon ezrin/radixin/moesin (ERM) that is phosphorylated by LRRK2 and LRRK2 mutants.For use in combination with深入閱讀
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產品號碼Quantity
PV49011 mg
產品號碼 PV4901
價格 (TWD)
-
Quantity:
1 mg
A fluorescein-labeled peptide substrate based upon ezrin/radixin/moesin (ERM) that is phosphorylated by LRRK2 and LRRK2 mutants.

For use in combination with the LanthaScreen™ Tb-anti-ERM (pLRRKtide) Antibody (PV4899) to evalute inhibitors in medium to high throughput screening applications.
For Research Use Only. Not for use in diagnostic procedures.
規格
Amino Acid SequenceFluorescein-GAGRLGRDKYKTLRQIRQ
Assay EntryBiochemical terbium phospho-specific activity
Gene ID (Entrez)120892
Label or DyeFITC (Fluorescein)
Molecular Weight (g/mol)2475.8 Da
Quantity1 mg
Shipping ConditionDry Ice
SubstrateERM (LRRKtide)
Target EntryLRRK2 D1994A, LRRK2 R1441C, LRRK2 I2020T, LRRK2 G2019S, LRRK2
Validated KinasesLRRK2
Detection MethodFluorescence
Substrate PropertiesPeptide-Based Substrate
Substrate TypeKinase Substrate
Target EnzymeSerine/Threonine Kinases
Unit SizeEach
內容物與存放
400 μM Fluorescein-ERM (LRRKtide) peptide substrate in water. Store at -20°C and protect from light.

引用資料與參考文獻 (1)

引用資料與參考文獻
Abstract
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.
Authors:Anand VS, Reichling LJ, Lipinski K, Stochaj W, Duan W, Kelleher K, Pungaliya P, Brown EL, Reinhart PH, Somberg R, Hirst WD, Riddle SM, Steven P B,
Journal:FEBS J
PubMed ID:19076219
Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the leading cause of autosomal dominant Parkinson's disease, with age of onset and symptoms identical to those of idiopathic forms of the disorder. Several of these pathogenic mutations are thought to affect its kinase activity, so understanding the roles of LRRK2, and ... More