The panel of assays in the TaqMan® Array 96-well Human MAP Kinase Pathways Plate targets genes from the four major groups of mammalian MAPKs: 1) ERKs (Extracellular signal-Regulated Kinases); 2) p38 MAPKs; 3) JNKs (c-Jun NH2-terminal Kinases); and 4) ERK5 (or BMK cascades). Genes from the MAP2K (MAPKK), MAP3K (MAPKKK), and dual-specificity protein kinase MAPKK (DUSP) groups are also on the panel. Other groups of kinases in this panel include: cyclin dependent kinase (CDK), MA ...P kinase interacting serine/threonine kinase (MNK), p21 activated kinases (PAK), and ribosomal S6 kinases (RSK). Several MAPK targets including genes associated with signal transduction, transcription regulation, cell cycle regulation and cancer are also included.
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ARAF, ATF2, BRAF, CCND1, CCNE1, CDC42, CDKN1B, CDKN1C, CHUK, COL1A1, CREB1, CREBBP, DUSP1, DUSP10, DUSP16, DUSP2, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, FOS, GRB2, HRAS, IGF1, KRAS, MADD, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3...K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK15, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MEF2A, MEF2C, MKNK1, MKNK2, MYC, NLK, NRAS, PAK1, PAK2, PAK3, PAK4, PTK2B, RAC1, RAF1, RELA, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, TP53, ZAK
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The MAPKs (Mitogen-Activated Protein Kinases) are a group of protein Serine/Threonine Kinases that are activated in response to a variety of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. In combination with se ...veral other signaling pathways, they can differentially alter the phosphorylation status of numerous proteins including Transcription Factors, Cytoskeletal proteins, Kinases and other Enzymes. They play major roles in gene expression, metabolism, cell division, cell morphology and cell survival. Aberrations of these enzymes or of the signaling cascades that regulate them have been implicated in many human diseases including cancer, inflammation, and cardiovascular disease.
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