AKT1, ARAF, BAX, BCL2, BRAF, CCL2, CD4, CHUK, CXCL12, FRAP1, GRB2, HRAS, IKBKB, IKBKE, IKBKG, IL10, IL18, IL1A, IL1B, IL2, IL4, IL6, IL6R, IL6ST, IL8, JAK3, KRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAPK1, MAPK12, MAPK3, MAPK6, MAPK7, MRAS, MYC, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIAS3, PIK3C2A, PI...K3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PIK3R2, PIK3R3, PIK3R4, PIK3R5, PIM1, PPP1R12A, PPP1R15A, PPP1R1B, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R4, PPP2R5A, PPP2R5C, PTPN11, PTPN6, RAF1, REL, RELA, RELB, RRAS, RRAS2, SHC1, SHC2, SHC3, SOCS1, SOCS2, SOCS3, SOCS5, SOCS6, STAT3, TIMP1, TNF, TP53BP2
View More... View Less...

IL-6 (Interleukin-6) is a cytokine that provokes a broad range of cellular and physiological responses, including the immune response, inflammation, hematopoiesis, and oncogenesis by regulating cell growth, gene activation, proliferation, survival, and di ...fferentiation. IL-6 signals through a receptor composed of two different subunits, an alpha subunit that produces ligand specificity and GP (Glycoprotein) 130, a receptor subunit shared in common with other cytokines in the IL-6 family. Binding of IL-6 to its receptor initiates cellular events including activation of JAK (Janus Kinase) kinases and activation of Ras-mediated signaling. Activated JAK kinases phosphorylate and activate STAT transcription factors, particularly STAT3 (Signal Transducers and Activators of Transcription-3) and SHP2 [SH2 (Src Homology-2) Domain-containing Tyrosine Phosphatase]. Phosphorylated STAT3 then forms a dimer and translocates into the nucleus to activate transcription of genes containing STAT3 response elements. STAT3 is essential for GP130-mediated cell survival and G1 to S cell-cycle-transition signals. Both c-Myc and Pim have been identified as target genes of STAT3 and together can compensate for STAT3 in cell survival and cell-cycle transition. SHP2 links cytokine receptor to the Ras/MAP (Mitogen-Activated Protein) kinase pathway and is essential for mitogenic activity.
View More... View Less...