The panel of assays in the TaqMan® Array 96-well Human Alzheimer's Disease Plate is based on the ‘amyloid hypothesis’. The 92 genes are involved in APP processes that generate beta-amyloid and included genes implicated in multiple secondary steps of beta-amyloid aggregation, tau hyperphosphorylation, excitotoxicity, inflammation, oxidation and microglial activation. We also include assays for genes involved in cholesterol biosynthesis due to the correlation between high chol ...esterol and increased risk of Alzheimer's. Genes associated with Alzheimer's disease pathology, biochemistry and genetics are also included.
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ABCA1, ACHE, ADAM10, ADAM17, ADAM9, AGER, APBA1, APBA2, APBA3, APBB1, APBB2, APBB3, APCS, APH1A, APH1B, APLP1, APLP2, APOE, APP, BACE1, BACE2, BCHE, BPTF, CAPN1, CAPNS1, CAPNS2, CASP3, CASP6, CDC2, CDK5, CDK5R1, CHRM1, CHRM3, CHRNA4, CHRNA7, CSNK1A1, CSNK1D, CTSB, CTSC, CTSD, CTSG, CYP46A1, GAL, GAP43, GJB1, GLS, GRIN1..., GRIN2A, GRIN2B, GRIN2C, GRIN2D, GSK3B, HSD17B10, IDE, IFNG, IL1A, IL1B, IL6, INS, INSR, LRP1, LRP2, LRPAP1, MAPK1, MAPK3, MAPT, MME, NAE1, NCSTN, PDE8B, PKN1, PLD1, PPP2CA, PRKACB, PRKCA, PRKCB1, PRKCE, PRKCG, PSEN1, PSEN2, PSENEN, SERPINA3, SLC18A3, SLC30A3, SNCA, SOAT1, SOD2, ST6GAL1, TNF, UBQLN1, UCHL1, VSNL1
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Alzheimer’s disease is a progressive and fatal neurodegenerative disorder. The disease has a characteristic neuropathology—cerebral plaques containing beta-amyloid deposits and neurofibrillary tangles composed of the microtubule-associated protein tau. Th ...ere is strong evidence that generation and deposition of beta-amyloid has a pivotal role in pathogenesis.
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