ADCY1, ADCY3, AKT1, ATF1, ATF4, CACNA1C, CACNA1F, CACNA1G, CACNA1H, CACNA1S, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CREB1, CREBBP, CREM, EGFR, ELK1, EP300, FLT1, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GNB1, GNB2, GNB3, GNG2, GRB2, GRIA1, GRIA2, GRIA3, GRIA4, GRIK2, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM...8, GTF2B, HRAS, IL2, IL6, ITPR1, ITPR2, ITPR3, KDR, KIT, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAPK1, MAPK3, MET, PIK3CA, PIK3CB, PIK3CD, PIK3R1, PIK3R2, PLCB1, PLCB2, PLCE1, PLCG1, PLCG2, POLR2A, POLR2B, POLR2C, PRKACA, PRKACB, PRKAR1A, PRKAR2A, PRKAR2B, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCZ, RAF1, SOS1, TBP, TGFB1
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The process of consolidating a new memory and the dynamic complexity of information processing within neuronal networks is greatly increased by activity-dependent changes in gene expression within individual neurons. A leading paradigm of such regulation ...is the activation of the nuclear transcription factor CREB (cAMP Responsive Element Binding Protein),and its family members the ATF (Activating Transcription Factor) and CREM (cAMP Response Element Modulator),which belong to bZIP (basic lucine zipper) class of transcription factors that functions in vivo to regulate the proliferation of pituitary cells and thymocytes. Proteins belonging to this class are characterized by the ability to bind to the consensus sequence TGACGTCA and contain a leucine zipper responsible for DNA binding (basic region) and for dimerization (leucine zipper region) of the proteins. CREB can form homodimers or heterodimers with other members of the ATF family, including ATF1 and CREM. However, heterodimerization of CREB with other members of the ATF family decreases its stability and CRE (cAMP Responsive Element) binding affinity.
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