AHR, AR, ARNT, BRD8, COPS2, CREBBP, DDX5, ESR1, ESR2, ESRRA, ESRRB, ESRRG, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HMGA1, HNF4A, HNF4G, ITGB3BP, KAT2B, KAT5, MED1, MED12, MED13, MED14, MED16, MED17, MED24, MED4, MTA1, NCOA1, NCOA2, NCOA3, NCOA4, NCOA6, NCOR1, NCOR2, NFKB2, NONO, NOTCH2, NR0B1, NR0B2, NR1D1, NR...1D2, NR1H2, NR1H3, NR1H4, NR1I2, NR1I3, NR2C1, NR2C2, NR2E1, NR2E3, NR2F1, NR2F2, NR2F6, NR3C1, NR3C2, NR4A1, NR4A2, NR4A3, NR5A1, NR5A2, NR6A1, NRIP1, PGR, PPARA, PPARD, PPARG, PPARGC1A, PPARGC1B, PSMC3, PSMC5, RARA, RARB, RARG, RBPJ, RORA, RORB, RORC, RXRA, RXRB, RXRG, TGS1, THRA, THRB, TRIP4, VDR
View More... View Less...

Nuclear hormone receptors (NRs) are ligand-activated intracellular transcription factors that have profound effects on development, homeostasis and detoxification. Ligands that are recognized by NRs include: endogenous hormones, vitamins A and D, drugs an ...d xenobiotic compounds. Several NRs, called orphan receptors, have no known endogenous ligands. Their low affinity for fatty acids, bile acids and/or sterols (e.g., FXR, LXR and PPAR) suggests that they function as metabolic sensors. Other NRs act as xenobiotic sensors by up-regulating the expression of cytochrome P450 enzymes that are xenobiotic metabolizers. NRs function with co-activators and co-repressors to up- or down-regulate the expression of genes and can regulate the expression of a large number of genes. The NR family is highly conserved in vertebrates. They have a modular domain structure consisting of a DNA-binding domain and a ligand-binding domain. Other domains include a modulatory A/B domain, the hinge D domain, and a variable C-terminal F domain that is missing in some NRs.
View More... View Less...