AHR (Aryl Hydrocarbon Receptor) is a member of the bHLH (basic Helix-Loop-Helix)- PAS (PerARNT-Sim) family of transcriptional regulators. AHR, also known as the Dioxin receptor, is recognized as the culprit for most toxic responses observed after exposure ... to PAH (Polycyclic Aromatic Hydrocarbons), Dioxins (e.g. TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin)),and Polychlorinated Biphenyls. Ligands for AHR are diverse which include dietary compounds, natural and synthetic flavonoids, natural products, and pharmaceuticals. AHR can affect cellular signaling through interactions with various Regulatory and Signaling proteins, including PAS heterodimerization partners ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator),Chaperone and Immunophilin-like proteins (e.g. HSP90 (Heat Shock Protein-90),AIP (Aryl Hydrocarbon Receptor-Interacting Protein),p23)),Protein Kinases and Phosphatases (e.g. Tyrosine Kinases,CK2 (Casein Kinase-2),PKC (Protein Kinase-C)),and Coactivators (e.g. SRC1(Steroid Receptor Coactivator-1),RIP140,CBP (CREB-Binding Protein)/p300). In addition, AHR is also known to interact with signaling pathways that are mediated by ESR (Estrogen Receptor) and other Hormone receptors, Hypoxia, NF-KappaB (Nuclear Factor-Kappa-B) and Rb (Retinoblastoma) protein.
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