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BDNF (brain derived neurotrophic factor) is a member of the nerve growth factor family, and a prevalent growth factor of the central nervous system. BDNF is important for neuronal plasticity and survival, and maintenance of specific neuronal populations like striatal neurons. It is also involved in long-term learning and memory formation. BDNF is expressed in a glycosylated 28 kDa form containing a prodomain required for trafficking. Only after secretion is the propeptide removed by plasmin present in blood serum. BDNF has distinct isoforms derived from multiple transcript variants.
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