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The protein encoded by this gene is a noncollagenous extracellular matrix protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia and multiple epiphyseal dysplasia .
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