Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.
Your search for "dio3" returned 45 TaqMan® Gene Expression Assays
deiodinase, iodothyronine, type III
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, May 2016]
|Protocol||Protocol: TaqMan® Gene Expression Assays||PDF, 2349.1 KB|
|App Note||Application Note: TaqMan® Gene Expression Assays Endogenous Controls||PDF, 493.8 KB|
|QRC||QRC: TaqMan® Gene Expression Assays||PDF, 200.9 KB|
|White Paper||Design Process for Gene Expression Assays||PDF, 943.6 KB|
|White Paper||Gene Expression Assay Performance Guarantee||PDF, 481.9 KB|
|White Paper||TaqMan® Assays shipped at ambient temperature retain their quality and stability||PDF, 3255.7 KB|
|Brochure||Understanding Your Shipment||PDF, 3726.3 KB|
|White Paper||Product Stability Study||PDF, 446.0 KB|
|Spreadsheet||Pathogen Assay Information||XLSX, 4231.7 KB|
Please enter the information below and press OK to send your cart to Core Services for purchase.